Clinical Research Directory

Inclusion Criteria: * Patient followed at the Victor Hugo Clinic, Le Mans. * Patients aged \>or= 18 and \< 80 years old at the time of inclusion * Patients with a histologically proven primary breast cancer from stage I to IIIc * Naive patient of anti-cancer treatment for this cancer * Agreement to participate in the study by written, informed and signed consent of the patient * Affiliated patients or beneficiaries of a social security scheme * ECOG Performance Status score ≤ 2 Exclusion Criteria: * Comorbidity which can explain the symptoms of fatigue (Long-term illness other than cancer, chronic fatigue syndrome) * Breathing difficulties requiring the use of respiratory assistance * Signs of polyneuropathy, amyotrophy or myasthenic syndrome * Contraindications to physical exercise linked to heart failure. * Treatment based on psychostimulants, psychotropics, antidepressants, antiepileptics or benzodiazepines for more than 3 months at the time of the study * Presence or history of psychosis, bipolarity or severe depression * History of stroke * History of chronic fatigue * History of musculoskeletal disorders of the lower limbs * Pregnancy, breastfeeding * Patient unable to undergo protocol monitoring for psychological, social, family or geographic reasons