Clinical Research Directory
Browse clinical research sites, groups, and studies.
Preoperative Nutrition for Crohn's Disease Patients
Sponsor: Tel-Aviv Sourasky Medical Center
Summary
The investigator hypothesizes that compliance to Exclusive enteral nutrition (EEN) will be high among patients on an operation for their bowel disease, compared to the compliance rate seen in the general Crohn's Disease (CD) population. Also,the investigator hypothesizes that clinical outcomes would improve, and post-operative complication rate will be reduces in malnourished CD patients receiving pre-operative 4 weeks EEN during the 4 weeks post-surgery, compared to CD patients receiving high energy and protein diet without EEN.
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
144
Start Date
2020-09
Completion Date
2027-12
Last Updated
2020-05-21
Healthy Volunteers
No
Conditions
Interventions
Exclusive Enteral Nutrition
Mulnourished patients will drink an enteral polymeric formula suited to their energy expenditure calculated by 25-30 kcal/kg and at least 1 gr/kg of protein, a minimum of 1500 ml (1500 kcal, 54 gr of protein). The amount of formula to achieve nutritional requirements are based on body weight, but the average intake is of 6-8 cups of formula (36-48 scoops of formula mixed with 1260-1680 ml of water to achieve a concentration of 1 kcal per ml). During this period patients will be guided to avoid eating and drinking anything but the enteral formula. The formula will be supplied to the patients by the investigators. The formula used for this study will be VITAL - suitable for people with disease-related malnutrition and malabsorption. Vital 1.5kcal is peptide-based, nutritionally complete formulation for the dietary management of active phase of Crohn's disease. VITAL includes all the nutritional macro and micronutrients and can serve as a sole source of nutrition.
High energy / protein diet.
Mulnourished patients will receive a high energy / protein diet.
Standard nutrition
Well nurished patients will receive a standard nutrition
Locations (1)
Dep. of Gastroenterology, Tel Aviv Sourasky Medical Center
Tel Aviv, Israel