Clinical Research Directory

Inclusion Criteria: Zika-exposed cohort: * born to mothers with Zika lab confirmation by PCR, IgM, and/or PRNT, or mother was symptomatic for Zika but infection could not be excluded due to late testing and evaluated at Children's National, Washington, DC (USA) or at BIOMELAB, Barranquilla (Colombia) * normal fetal neuroimaging * normal birth head circumference * normal birth clinical exam * no more than mild non-specific postnatal cranial ultrasound or brain MRI findings during infancy (if performed) * able to be contacted for follow-up Non-ZIKV exposed Controls: * healthy * no chronic medical conditions * no developmental concerns * born at term (\>= 37 weeks) * birth date prior to March 31, 2016 (Colombian controls) Exclusion Criteria: Zika-exposed cohort: * another diagnosis that would impact neurodevelopment * abnormal brain MRI (non-specific mild findings are not an exclusion criteria) Non-ZIKV exposed controls: * chronic medical condition with in-patient hospitalization since birth * under care of a medical specialty provider for a chronic medical condition * surgery with general anesthesia since birth (brief anesthesia for ear tubes, tonsillectomy, or other minor pediatric procedure is not an exclusion criteria) * history of seizure * abnormal vision (children wearing corrective lenses are eligible) * abnormal hearing affecting language development * developmental concerns expressed by caregiver * receiving physical, occupational, speech or developmental therapy * receiving special education services in school * behavioral or psychological condition * birth date March 31, 2016 or later (Colombian controls) * preterm birth (≤36 weeks) * planned relocation of child within 5 years and likely inability to complete study