Clinical Research Directory

Inclusion Criteria: * Hospitalized patients with probable COVID-19. Probable is defined as Influenza like illness (ILI) symptoms OR confirmed COVID-19 exposure AND COVID-19 testing performed. ILI is defined as any one of the following symptoms including: fever, new or worsening cough, coryza, new or worsening dyspnea, or sore throat. * Goals of care are do-not-intubate (R3 or M1/M2 in Alberta). * Need for oxygen ≥2 L to maintain SpO2 ≥92%. If the patient is on long-term oxygen, the O2 requirements must be ≥2 L above their baseline. * Patient can be positioned to and from prone to supine with minimal assistance (maximum one person assistance). Exclusion Criteria: * Decreased level of consciousness (Glasgow Coma Scale \< 10) or precluding ability to self-reposition. * Hemodynamic instability (Systolic Blood Pressure \< 90 mmHg and or Lactate \>5 mmol/L or HR \>120, not responsive to fluid resuscitation). * Complete bowel obstruction. * Active upper gastrointestinal bleeding. * Poor neck mobility or patient inability to lie prone comfortably. * Unstable spine, femur, or pelvic fractures. * Pregnancy - third trimester. * Full resuscitation status including ICU and willingness to accept invasive mechanical ventilation (i.e. R1/R2 goals of care). * Imminent palliation or end of life expected on admission (i.e. C1/C2 goals of care).