Clinical Research Directory
Browse clinical research sites, groups, and studies.
Treatment of Tinnitus With Migraine Medications
Sponsor: University of California, Irvine
Summary
Tinnitus represents one of the most common and distressing otologic problems, and it causes various somatic and psychological disorders that interfere with the quality of life. In addition, it contributes significant costs to the healthcare system. However, the mechanisms of tinnitus are poorly understood. and there is currently no FDA-approved medication to treat this condition. Current pharmacological treatment options address the stress, anxiety, and depression that are caused by tinnitus. There is an increased evidence of an epidemiological and mechanistic association between tinnitus and migraine. Therefore, in this study, we intended to evaluate the effectiveness of two combinations of migraine medications on patients with moderate to severe tinnitus by comparing them to placebo.
Official title: Treatment of Tinnitus With Migraine Medications: A Randomized Clinical Trial
Key Details
Gender
All
Age Range
25 Years - 85 Years
Study Type
INTERVENTIONAL
Enrollment
78
Start Date
2019-09-26
Completion Date
2023-12-30
Last Updated
2026-04-16
Healthy Volunteers
No
Conditions
Interventions
Nortriptyline + Topiramate
Group NT
Verapamil + Paroxetine
Group VP
Placebo
Group P
Locations (1)
University of California, Irvine Medical Center ENT Clinic (Pavilion 2)
Orange, California, United States