Clinical Research Directory

Inclusion Criteria: * Males or females, age 18-80 years admitted to a general medicine and surgery services * Known history of T2D receiving OADs either as monotherapy or in combination therapy * Admission BG \< 250 mg/dl or randomization BG \<250 mg/dl and not receiving basal insulin * Patients receiving OADs in combination with GLP-1 receptor agonists (GLP-1RA) who have HbA1c \<7.5% within the past three months * HbA1c \<10% Exclusion Criteria: * No known history of diabetes * Laboratory evidence of diabetic ketoacidosis * Subjects with a history of type 1 diabetes (suggested by BMI \< 25 requiring insulin therapy or with a history of diabetic ketoacidosis, or ketonuria) * Meeting any exclusion criteria based on specific contraindications to their home oral therapy * Acute critical illness or cardiac surgery expected to require admission to a critical care unit * Gastrointestinal obstruction, adynamic ileus, or expected to require gastrointestinal suction * Medical or surgical patients expected to be kept NPO for \>24-48 hours after admission or after completion of surgical procedure * Impaired renal function (eGFR \<30 ml/min) * Current treatment with oral or injectable corticosteroid * Mental condition rendering the subject unable to understand the nature and scope of the study * Female subjects who are pregnant or breastfeeding at time of enrollment in the study * New or recent onset (within two weeks) of coronavirus disease 2019 (COVID-19) infection at the time of admission