Clinical Research Directory

Inclusion Criteria: * Age 18 to 70 years old, female. * Patients with histologically confirmed unilateral primary invasive breast cancer who meet the criteria of cT2-4NanyM0. * Patients with ER negative and PR negative by immunohistochemistry (IHC), and HER-2 negative disease. HER2-negative disease was defined as follows: disease whose HER-2 is 1+ or negative by IHC, or fluorescence in situ hybridization (FISH) is negative if IHC is 2+. * According to the RECIST 1.1 criteria, there is at least one measurable objective lesion. * Eastern Cooperative Oncology Group (ECOG) performance score 0-1. * Baseline left ventricular ejection fraction (LVEF) is greater than or equal to (\>/=) 55%. * Bone marrow function is required as follows: neutrophils are more than or equal to (\>/=) 1.5×109/L, platelets more than or equal to (\>/=) 100×109/L, and hemoglobin more than or equal to (\>/=) 90g/L. * Hepatic and renal function are required as follows: serum creatinine is less than or equal to (\</=) 1.5 times of upper limits of normal (ULN), aspartate transaminase (AST) and alanine aminotransferase (ALT) less than or equal to (\</=) 2.5 times of ULN, and total bilirubin less than or equal to (\</=) 1.5 times of ULN or \</= 2.5 times of ULN if patient is with Gilbert's syndrome. * With good compliance with the planned treatment, are able to understand the follow-up procedures of this study and sigh the informed consent form. Signed informed consent. Exclusion Criteria: * Received radiotherapy, chemotherapy, surgery or other targeted and immunotherapy for triple-negative breast cancer before enrollment. * With heart disease classified as New York Heart Association class (NYHA) grade II or above (including grade II) are identified by the investigator. * With severe systemic infection or those with other serious illnesses. * Known to be allergic or intolerant to chemotherapy drugs or their excipients. * With a history of autoimmune diseases or those using glucocorticoids or immunosuppressive drugs. * With known active stage of HBV or HCV infection or hepatitis B DNA ≥500, or patients with chronic abnormal liver function. * With a history of abnormal thyroid function. * With grade ≥ 2 peripheral neuropathy. * With a clear history of neurological or mental disorders, including epilepsy or dement. * Previous non-breast malignancy within 5 years prior to study entry excluding healed cervical carcinoma in situ and non-melanoma skin cancer. * History of other malignant tumors within the past 5 years, excluding cured cervical carcinoma in situ and non-melanoma skin cancer. * Pregnancy or lactation, and patients of childbearing potential who refuse to use adequate contraception during the course of this study. * Prior participation in other studies within 30 days prior to the administration of the first dose of the investigational drug. * Patients who are deemed to be unsuitable for this study by investigators.