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COMPLETED
NCT04418999
EARLY_PHASE1

Safety and Efficacy of Intracanalicular Dexamethasone Compared to Loteprednol Etabonate in Patients With Keratoconus

Sponsor: Illinois College of Optometry

View on ClinicalTrials.gov

Summary

Drug delivery platforms are an innovative exciting advancement in ophthalmology. They allow patients to eliminate topical medications which are generally associated with lack of compliance, difficulty of use and requiring help from family members. These delivery systems can be applied easily in office, and patients do not have to worry about drop insertion in their post-operative regimen. The results of this research project should help to answer the following question: Does the use of a physician administered intracanalicular dexamethasone insert improve the signs and symptoms of ocular allergy and dry eye disease in KC patients compared to the use of topical loteprednol etabonate ophthalmic gel 0.38%?

Official title: Safety and Efficacy of Intracanalicular Dexamethasone Insert Compared to Loteprednol Etabonate Ophthalmic Gel 0.38% in Patients With Keratoconus Wearing Gas Permeable Contact Lenses Who Have Been Diagnosed With Allergic Conjunctivitis

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

36

Start Date

2020-09-01

Completion Date

2021-12-31

Last Updated

2026-06-24

Healthy Volunteers

Yes

Interventions

DRUG

dexamethasone ophthalmic insert 0.4 mg, for intracanalicular use

Experimental

DRUG

Loteprednol Etabonate 0.38% Ophthalmic Gel/Jelly

Active Comparator

Locations (1)

Illinois Eye Institute

Chicago, Illinois, United States