Clinical Research Directory

Inclusion Criteria: * Have type 2 diabetes mellitus (T2DM) for at least 6 months * Have a glycated hemoglobin (HbA1c) value at screening of greater than or equal to (≥)7.0 percent (%) and less than or equal to (≤)10.5% and are treated with diet and exercise alone or a stable dose of metformin for at least 3 months prior to screening * Have a body weight of ≥45 kilograms (kg) and have a body mass index of 18.5 to 45 kilograms per square meter (kg/m²), inclusive * Have had a stable body weight for the 3 months prior to screening (less than \[\<\]5% body weight change) * Males and females (not considered woman of childbearing potential) Exclusion Criteria: * Have type 1 diabetes mellitus, latent autoimmune diabetes in adults or have had an episode of ketoacidosis or hyperosmolar state requiring hospitalization in the 6 months prior to screening * Have had any of the following within the past 6 months prior to screening: myocardial infarction, unstable angina, coronary artery bypass graft, percutaneous coronary intervention (diagnostic angiograms are permitted), transient ischemic attack, cerebrovascular accident or decompensated congestive heart failure, or currently have New York Health Association Class III or IV heart failure * Show evidence of hepatitis B, and/or positive hepatitis B surface antigen * Show evidence of human immunodeficiency virus (HIV) infection and/or positive human HIV antibodies * Any glucose-lowering medications other than metformin within 3 months prior to screening