Clinical Research Directory

Inclusion Criteria: * 18 years of age and older * Proband must be carrier of a high risk cancer predisposition gene * Relative must be established relative of respective proband participant and deemed "at-risk" for familial gene mutation and eligible genetic testing candidate as per study team determination * Participants must be able to understand and read English * Participants must be able to provide informed verbal or written consent Exclusion Criteria: * \<18 years of age * Individuals who are mutation negative for high risk cancer predisposition genes * Individuals who are carriers of a variant of uncertain significance in any gene * Individuals who test positive for more than 1 high risk cancer predisposition gene * Individuals who cannot speak and read English * Individuals who do not have any at-risk relatives (eligible for familial gene mutation testing) as per study team determination * Major psychiatric illness or cognitive impairment that in the judgement of the study investigators or study staff would preclude study participation * Any patients who are unable to comply with the study procedures as determined by the study investigators or study staff * No available family members for cascade opportunity (adoption, estrangement, etc.)