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JSP191 Antibody Conditioning Regimen in MDS/AML Subjects Undergoing Allogenic Hematopoietic Stem Cell Transplantation
Sponsor: Jasper Therapeutics, Inc.
Summary
This is a Phase 1a/b study to evaluate the safety and tolerability of an antibody conditioning regimen known as JSP191, in combination with low dose radiation and fludarabine, in subjects with Myelodysplastic Syndrome (MDS) or Acute Myeloid Leukemia (AML) undergoing allogenic blood stem cell transplantation.
Official title: A Phase 1a/b Study to Evaluate the Safety & Tolerability of JSP191 in Combination With a Regimen of Low Dose Radiation & Fludarabine in Subjects With MDS or AML Undergoing Hematopoietic Cell Transplantation (HCT)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
32
Start Date
2020-07-08
Completion Date
2023-06-13
Last Updated
2026-09-28
Healthy Volunteers
No
Interventions
Humanized anti-CD117 Monoclonal Antibody (JSP191)
Procedure: single intravenous infusion of JSP191 antibody
Locations (6)
City of Hope Comprehensive Cancer Center
Duarte, California, United States
Stanford University
Stanford, California, United States
Rush University Medical Center
Chicago, Illinois, United States
Oregon Health & Science University
Portland, Oregon, United States
Huntsman Cancer Institute - University of Utah
Salt Lake City, Utah, United States
Fred Hutchinson Cancer Research Center
Seattle, Washington, United States