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COMPLETED
NCT04429191
PHASE1

JSP191 Antibody Conditioning Regimen in MDS/AML Subjects Undergoing Allogenic Hematopoietic Stem Cell Transplantation

Sponsor: Jasper Therapeutics, Inc.

View on ClinicalTrials.gov

Summary

This is a Phase 1a/b study to evaluate the safety and tolerability of an antibody conditioning regimen known as JSP191, in combination with low dose radiation and fludarabine, in subjects with Myelodysplastic Syndrome (MDS) or Acute Myeloid Leukemia (AML) undergoing allogenic blood stem cell transplantation.

Official title: A Phase 1a/b Study to Evaluate the Safety & Tolerability of JSP191 in Combination With a Regimen of Low Dose Radiation & Fludarabine in Subjects With MDS or AML Undergoing Hematopoietic Cell Transplantation (HCT)

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

32

Start Date

2020-07-08

Completion Date

2023-06-13

Last Updated

2026-09-28

Healthy Volunteers

No

Interventions

BIOLOGICAL

Humanized anti-CD117 Monoclonal Antibody (JSP191)

Procedure: single intravenous infusion of JSP191 antibody

Locations (6)

City of Hope Comprehensive Cancer Center

Duarte, California, United States

Stanford University

Stanford, California, United States

Rush University Medical Center

Chicago, Illinois, United States

Oregon Health & Science University

Portland, Oregon, United States

Huntsman Cancer Institute - University of Utah

Salt Lake City, Utah, United States

Fred Hutchinson Cancer Research Center

Seattle, Washington, United States