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Treatment of Sebaceous Hyperplasia With PDL and Nd:YAG Versus Erbium:YAG: A Randomized Controlled Trial
Sponsor: Northwestern University
Summary
The purpose of this study is to compare treatment of sebaceous hyperplasia with pulsed dye laser (PDL) plus neodymium doped yttrium aluminum garnet laser (Nd:YAG) versus erbium doped yttrium aluminum garnet (erbium:YAG) laser versus electrodesiccation and curettage (ED\&C). This is a randomized clinical trial. Approximately 18 participants will enrolled. Each participant will have their sebaceous hyperplasia lesions randomized to receive either Erbium:YAG, PDL plus Nd:YAG, or ED\&C treatment. Solitary lesions will be randomized to a group, thus, a patient may receive all three treatments, each on different lesions. Lesions will be treated twice, 2-6 weeks after the first treatment. Lesion size and count will be measured before treatment and at follow-up 4-12 weeks after the first treatment. This study is a pilot study designed to determine the feasibility of these procedures. Subjects currently living in the Chicago metropolitan area and meet inclusion/exclusion criteria will be considered for enrollment.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
18
Start Date
2025-07
Completion Date
2026-12
Last Updated
2025-05-08
Healthy Volunteers
Yes
Conditions
Interventions
Erbium:YAG Laser
Erbium:YAG 2940nm will be performed using single spot, multiple pulses on lesions.
Pulsed Dye Laser
PDL will be performed using settings of 6-10 J/s2 on lesions.
Nd:YAG Laser
Nd:YAG 1064nm will be performed using settings of 60-110 J/s2 on lesions.
Electrodessication and curettage
Electrodessication and curettage will be performed using an epilating needle, followed by curettage on lesions.
Locations (1)
Northwestern University Department of Dermatology
Chicago, Illinois, United States