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Heterozygous Individuals for AGXT and Kidney Stones
Sponsor: University of Alabama at Birmingham
Summary
This study seeks to examine the effects of a heterozygous mutation of the AGXT gene in a stone forming population on endogenous oxalate production. Participants will consume a controlled low-oxalate diet and provide blood and urine samples to measure the amount of oxalate in their bodies. Subjects will then be administered an intravenous (IV) load of glycolate, providing additional blood and urine samples afterwards to measure any increase in oxalate levels.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
4
Start Date
2026-07-01
Completion Date
2032-08-01
Last Updated
2025-07-04
Healthy Volunteers
No
Conditions
Interventions
Controlled Diet
Participants will consume a controlled low oxalate diet for five days.
Glycolate Administration
Participants will come to the UAB Clinical Research Unit (CRU) and be administered a glycolate load via intravenous (IV) catheter.