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Sex Disparities in Hypoxic Sympatholysis and Impact of Obesity
Sponsor: University of Missouri-Columbia
Summary
Patients with sleep apnea are at increased risk of developing cardiovascular disease - with women at potentially greater risk than men. Contributing mechanisms are not well understood, but may be related to how women respond to low oxygen and, given over 70% of patients with sleep apnea are obese, the impact of obesity. This project seeks to increase our understanding of mechanisms that may contribute to sex differences in the cardiovascular response to low oxygen with the hope that this knowledge will improve the efficacy of current therapies and support the discovery of novel therapeutics.
Key Details
Gender
All
Age Range
18 Years - 45 Years
Study Type
INTERVENTIONAL
Enrollment
104
Start Date
2020-12-09
Completion Date
2026-06-30
Last Updated
2025-06-04
Healthy Volunteers
Yes
Interventions
Hypoxia Exposure
Systemic oxygen levels will be titrated to attain hypoxemia as assessed by pulse oximetry.
Phenylephrine
Phenylephrine (0.0625 mcg/dL/min) will be locally infused via brachial artery catheter during the final 3 min of normoxia and hypoxia.
Dexmedetomidine
Dexmedetomidine (12.5 ng/dL/min) will be locally infused via brachial artery catheter during the final 3 min of normoxia and hypoxia.
Phentolamine
Phentolamine will be locally infused via brachial artery catheter for 10 min before baseline measurement (12 mcg/dL/min) and the infusion will continue at a maintenance rate (5 mcg/dL/min) during acute normoxia and hypoxia.
Norepinephrine
Regional forearm infusion at 8 ng/dL/min via brachial artery catheter during normoxia and hypoxia exposures
Locations (1)
University of Missouri-Columbia
Columbia, Missouri, United States