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Renal Metabolism of Glycolate to Oxalate
Sponsor: University of Alabama at Birmingham
Summary
This study will determine the contribution of glycolate metabolism to urinary oxalate excretion in healthy subjects, using carbon 13 isotope glycolate tracer technique and a low-oxalate controlled diet.
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
15
Start Date
2020-03-12
Completion Date
2027-09-01
Last Updated
2025-12-19
Healthy Volunteers
Yes
Conditions
Interventions
Low oxalate controlled Diet
Participants will consume a diet that is controlled in its contents of protein, carbohydrates, fat, calcium, oxalate, vitamin C and sodium. Participants will be asked not to take any dietary supplements, exercise strenuously, or consume food or drink that is not provided to them.
Primed, continuous intravenous infusion of 13C2-Glycolate
Participants will receive a continuous intravenous administration of carbon-13 glycolate, a naturally occurring form of glycolate, over the course of several hours until steady-state is achieved, using an IV catheter.
Bolus intravenous infusion of 13C2-Glycolate
Participants will receive a bolus intravenous administration of carbon-13 glycolate, a naturally occurring form of glycolate, using an IV catheter.
Oral bolus administration of 13C2-Glycolate
Participants will orally ingest a single dose of carbon-13 glycolate, a naturally occurring form of glycolate.
Locations (1)
University of Alabama at Birmingham
Birmingham, Alabama, United States