Clinical Research Directory

Inclusion Criteria: * Patient aged 18 years or older * Patient is diagnosed with a degenerative spine disorder requiring spinal fusion, has failed conservative treatment, and has decided to undergo surgery. * The surgeon has determined that a NanoBone product is or was clinically indicated, and will use or have used the product as a stand-alone bone graft substitute or in combination with local autograft only (no iliac crest harvesting, other BGS, or biologic {defined as containing growth factors, cytokines, proteins, or cells} used). * Patient capable of understanding the content of the Informed Consent Form * Patient willing and able to participate in the registry protocol including SOC follow-up visits and clinical evaluations. * Patient who has agreed to participate in the registry by providing consent according to the applicable local law and the Declaration of Helsinki. Exclusion Criteria:• Severe vascular or neurological disease * Uncontrolled diabetes * Severe degenerative disease (other than degenerative disc disease) * Severely impaired renal function * Hypercalcemia, abnormal calcium metabolism * Existing acute or chronic infections, especially at the site of the operation * Inflammatory bone disease such as osteomyelitis * Malignant tumors * Patients who are or plan to become pregnant. * Uncooperative patients who cannot or will not follow post-operative instruction, including individuals who abuse drugs and/or alcohol.