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Autonomic Regulation of Blood Pressure in Premature and Early Menopausal Women
Sponsor: University of Minnesota
Summary
This is a cross-sectional study in which the investigators will determine the impact of premature/early menopause on MSNA, BP and baroreflex sensitivity in younger (≤49 yr old) and older (≥50 yr old) women. Specifically, aim one will determine mechanisms driving autonomic dysregulation of BP in premature and early menopausal women and aim two will determine mechanisms driving autonomic dysregulation of BP in older menopausal women. The study design outlined below will permit testing of aim one and aim two.
Key Details
Gender
FEMALE
Age Range
35 Years - 70 Years
Study Type
OBSERVATIONAL
Enrollment
160
Start Date
2019-10-01
Completion Date
2026-12-30
Last Updated
2026-01-08
Healthy Volunteers
Yes
Interventions
Microneurography to measure muscle sympathetic nerve activity (MSNA)
Microneurography is a direct measurement of electrical activity of peripheral sympathetic nerves
Baroreflex sensitivity testing
Two arms of the baroreflex that will be tested in this study are sympathetic and cardiovagal. Static baroreflex is tested during baseline resting conditions and dynamic baroreflex is tested during Valsalva maneuvers.
Sympathoexcitatory Maneuvers
Cold Pressor Test (CPT) and Upper extremity fatiguing contraction with post exercise circulatory occlusion (PECO) will be performed
Blood tests
Serum FSH, estrogen, progesterone, and testosterone will be measured
Locations (1)
University of Minnesota
Minneapolis, Minnesota, United States