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EEG-Guided Analgesic Titration During General Anesthesia to Improve Early Neurocognitive Recovery in Older Patients
Sponsor: Columbia University
Summary
The investigators intend to recruit 600 participants to see if alpha power during anesthesia is influenced by analgesic medication and associated with a reduction of delirium following surgery.
Key Details
Gender
All
Age Range
60 Years - Any
Study Type
INTERVENTIONAL
Enrollment
600
Start Date
2026-04-01
Completion Date
2031-03-31
Last Updated
2026-01-07
Healthy Volunteers
Yes
Conditions
Interventions
Alpha Optimization
Intraoperative oscillatory EEG alpha optimization involves real-time acquisition of oscillatory alpha power from the frontal EEG with individualized titration of sevoflurane and opioid.
Emergence from anesthesia with Dexmedetomidine
Infusion of .05 mcg/kg/h of propofol during the final 10-20 minutes of surgery.
Locations (1)
Columbia University Irving Medical Center
New York, New York, United States