Clinical Research Directory

Inclusion Criteria: * Performance status eligible for immune checkpoint blockade as determined by local physician * Able to demonstrate histologically proven locally advanced or metastatic solid tumors (hematologic malignancies and lymphoma excluded) * genomic testing demonstrating a spliceosome mutation (SF3B1, U2AF1 or SRSF2) Exclusion Criteria: * Local physician determines has known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the trial * Local physician determines the patient has a history or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the trial, interfere with the subject's participation for the full duration of the trial, or is not in the best interest of the subject to participate