Clinical Research Directory

Inclusion Criteria: * Male or non-pregnant female aged 21-55 years * Report non-medical use of cannabis 1-7 days per week over the 1 month prior to screening * Not currently seeking treatment for cannabis use * Urine test positive for recent cannabis use * Have a Body Mass Index from 18.5 - 34kg/m2. * Able to perform all study procedures * Must be using a contraceptive method (hormonal or barrier methods) Exclusion Criteria: * Meeting DSM-V criteria for any substance use disorder other than nicotine, caffeine, or mild CUD * Report using other illicit drugs in the prior 4 weeks * • If medical history, physical and psychiatric examination, or laboratory tests performed during the screening process not within the normal range and / or reveal any significant illness (e.g., hypertension) as judged by the study physician and to put the participant at greater risk of experiencing adverse events due to completion of study procedures. * Current licit use of cannabis primarily for medical purposes, prescription analgesics, or any medications that may affect study outcomes * Current pain * Pregnancy is exclusionary due to the possible effects of the study medication on fetal development. * History of an allergic reaction or adverse reaction to cannabis is exclusionary. * History of respiratory illness or current respiratory illness * History of seizure disorder or current seizure disorder * Insensitivity to the cold water stimulus of the Cold Pressor Test * Currently enrolled in another research protocol * Current major Axis 1 disorders (mood, anxiety, or psychotic disorder) * Not using a contraceptive method (hormonal or barrier methods) * The evaluating physician reviews all medical assessments along with medical history. Any disorders that might make cannabis administration hazardous are exclusionary.