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Prospective Exploratory Study of FAPi PET/CT With Histopathology Validation in Patients With Various Cancers
Sponsor: Jonsson Comprehensive Cancer Center
Summary
This exploratory study investigates how an imaging technique called 68Ga-FAPi-46 PET/CT can determine where and to which degree the FAPI tracer (68Ga-FAPi-46) accumulates in normal and cancer tissues in patients with cancer. Because some cancers take up 68Ga-FAPi-46 it can be seen with PET. FAP stands for Fibroblast Activation Protein. FAP is produced by cells that surround tumors (cancer associated fibroblasts). The function of FAP is not well understood but imaging studies have shown that FAP can be detected with FAPI PET/CT. Imaging FAP with FAPI PET/CT may in the future provide additional information about various cancers.
Official title: PET Biodistribution Study of 68Ga-FAPI-46 in Patients With Different Malignancies: An Exploratory Biodistribution Study With Histopathology Validation
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
26
Start Date
2020-08-27
Completion Date
2027-07-01
Last Updated
2026-02-05
Healthy Volunteers
No
Conditions
Interventions
Computed Tomography
Undergo PET/CT
Gallium Ga 68 FAPi-46
Given IV
Positron Emission Tomography
Undergo PET/CT
18F-FDG
Given IV
Locations (1)
UCLA / Jonsson Comprehensive Cancer Center
Los Angeles, California, United States