Clinical Research Directory
Browse clinical research sites, groups, and studies.
A Study of EPX-100 (Clemizole Hydrochloride) in Participants With Dravet Syndrome
Sponsor: Epygenix
Summary
This is a multicenter, Phase 3, randomized, double-blind, placebo-controlled study designed to evaluate the efficacy and safety of clemizole hydrochloride (EPX-100) as adjunctive therapy in children and adult participants with Dravet syndrome (DS).
Official title: A 20-Week Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of EPX-100 (Clemizole Hydrochloride) as Adjunctive Therapy in Children and Adult Participants With Dravet Syndrome (ARGUS Trial)
Key Details
Gender
All
Age Range
2 Years - Any
Study Type
INTERVENTIONAL
Enrollment
150
Start Date
2020-09-15
Completion Date
2029-05-01
Last Updated
2025-08-28
Healthy Volunteers
No
Conditions
Interventions
Clemizole HCl
Clemizole HCl will be administered as an oral solution.
Placebo
Placebo will be administered as an oral solution.
Locations (46)
Children's Hospital of Los Angeles
Los Angeles, California, United States
University of California Irvine
Orange, California, United States
UCSF Medical Center
San Francisco, California, United States
Yale University School of Medicine
New Haven, Connecticut, United States
The Nemours Foundation
Wilmington, Delaware, United States
Rare Disease Research FL
Kissimmee, Florida, United States
Pediatric Neurology and Epilepsy Specialists
Winter Park, Florida, United States
Clinical Integrative Research Center of Atlanta (CIRCA)
Atlanta, Georgia, United States
Ann & Robert H. Lurie Children's Hospital of Chicago
Chicago, Illinois, United States
Norton Children's Research Institute
Louisville, Kentucky, United States
University of Michigan- Mott Children's Hospital
Ann Arbor, Michigan, United States
Children's Nebraska
Omaha, Nebraska, United States
Northeast Regional Epilepsy Group
Hackensack, New Jersey, United States
Neurology Center for Epilepsy and Seizures
Marlboro, New Jersey, United States
Weill Cornell Medical Center
New York, New York, United States
Northwell Health - Lenox Hill Hospital
New York, New York, United States
Duke University Health System
Durham, North Carolina, United States
Wake Forest Baptist Medical Center
Winston-Salem, North Carolina, United States
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States
Cleveland Clinic
Cleveland, Ohio, United States
Nationwide Children's Hospital
Columbus, Ohio, United States
The Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States
Le Bonheur Children's Hospital
Memphis, Tennessee, United States
Child Neurology Consultants of Austin
Austin, Texas, United States
UT Southwestern/Children's Health
Dallas, Texas, United States
University of Utah
Salt Lake City, Utah, United States
Seattle Children's Hospital
Seattle, Washington, United States
UBC Children's Hospital Research Institute
Vancouver, British Columbia, Canada
Children's Hospital of Eastern Ontario Research Institute Inc.
Ottawa, Ontario, Canada
The Hospital for Sick Children
Toronto, Ontario, Canada
Toronto Western Hospital, University Health Network
Toronto, Ontario, Canada
Tbilisi State Medical University, Givi Zhvania Academic, Clinic of Pediatry
Tbilisi, Georgia
Medi Club Georgia LLC
Tbilisi, Georgia
Institute of Neurology and Neuropsychology LTD
Tbilisi, Georgia
Semmelweis University
Budapest, Hungary
University of Debrecen
Debrecen, Hungary
University Clinical Center in Gdansk, Division of Developmental Neurology
Gdansk, Poland
Medical Centre Plejady
Krakow, Poland
Institute of Mother and Child
Warsaw, Poland
"Prof. Dr. Al. Obregia" Psychiatry Clinical Hospital
Bucharest, Romania
Hospital Infantil Universitario Niño Jesús
Madrid, Madrid Provincia, Spain
Hospital de la Santa Creu i Sant Pau
Barcelona, Spain
Cardiff and Vale University Health Board
Cardiff, United Kingdom
Alder Hey Children's NHS Foundation Trust
Liverpool, United Kingdom
Great Ormond Street Hospital For Children
London, United Kingdom
Sheffield Children's Hospital
Sheffield, United Kingdom