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Study of Oral Navitoclax Tablet in Combination With Oral Ruxolitinib Tablet Versus Best Available Therapy to Assess Change in Spleen Volume in Adult Participants With Relapsed/Refractory Myelofibrosis
Sponsor: AbbVie
Summary
Myelofibrosis (MF) is a rare blood cancer, notable for scarring of the bone marrow (the spongy tissue inside bones) and the spleen becoming larger. The purpose of this study is to assess safety and change in spleen volume when navitoclax is given in combination with ruxolitinib, compared to best available therapy, for adult participants with MF. Navitoclax is an investigational drug (not yet approved) being developed for the treatment of MF. Participants in this study will be randomly selected (like picking numbers out of a hat) to be in 1 of 2 treatment arms. Neither participants nor the study doctor will be able to pick which treatment arm a participants enters. In Arm A, participants will receive navitoclax in combination with ruxolitinib. In Arm B, participants will receive the best available therapy (BAT) for MF. In Arm C, participants will receive navitoclax. Adult participants with a diagnosis of MF that came back or did not get better after earlier treatment will be enrolled. Approximately 330 participants will be enrolled in approximately 322 sites across the world. In Arm A, participants will receive navitoclax tablet by mouth once daily with by mouth ruxolitinib tablet twice daily. In Arm B, participants will receive the BAT available to the investigator. In Arm C, participants will receive navitoclax tablet by mouth once daily. Participants will receive the study drug until they experience no benefit (determined by the investigator), participants cannot tolerate the study drugs, or participants withdraw consent. The approximate treatment duration is about 3 years. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of treatment will be checked by medical assessments, blood and bone marrow tests, checking for side effects, and completing questionnaires.
Official title: Randomized, Open-Label, Phase 3 Study Evaluating Efficacy and Safety of Navitoclax in Combination With Ruxolitinib Versus Best Available Therapy in Subjects With Relapsed/Refractory Myelofibrosis (TRANSFORM-2), Incorporating Extension Arm C - Continued Access for Navitoclax to Roll Over Subjects From Studies M10-166, M16-109, M16-191, and M19-753
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
330
Start Date
2020-08-31
Completion Date
2026-12
Last Updated
2026-01-09
Healthy Volunteers
No
Conditions
Interventions
Navitoclax
Tablet; Oral
Ruxolitinib
Tablet; Oral
Best Available Therapy (BAT)
Tablet/Capsule; Oral or Solution for Subcutaneous Injection
Locations (229)
Ironwood Cancer & Res Ctr /ID# 222162
Chandler, Arizona, United States
Highlands Oncology Group, PA /ID# 221826
Springdale, Arkansas, United States
City of Hope /ID# 218996
Duarte, California, United States
Providence - St. Jude Medical Center /ID# 271382
Fullerton, California, United States
Moores Cancer Center /ID# 271596
La Jolla, California, United States
Moores Cancer Center at UC San Diego /ID# 219009
La Jolla, California, United States
Long Beach Memorial Medical Ct /ID# 224542
Long Beach, California, United States
Icri /Id# 221967
Whittier, California, United States
St. Mary's Hospital Regional Cancer Center /ID# 224229
Grand Junction, Colorado, United States
Augusta University Georgia Cancer Center /ID# 219051
Augusta, Georgia, United States
Columbus Regional Research Institute /ID# 224410
Columbus, Georgia, United States
University of Chicago Medical Center /ID# 271373
Chicago, Illinois, United States
Northwest Oncology & Hematology - Elk Grove Village /ID# 222818
Elk Grove Village, Illinois, United States
Loyola University Medical Ctr /ID# 219048
Maywood, Illinois, United States
Indiana Blood & Marrow Transpl /ID# 221587
Indianapolis, Indiana, United States
Tulane Medical Center - New Orleans /ID# 222940
New Orleans, Louisiana, United States
Duplicate_Ochsner Clinic Foundation-New Orleans /ID# 222777
New Orleans, Louisiana, United States
American Oncology Partners of Maryland /ID# 222836
Bethesda, Maryland, United States
Dana-Farber Cancer Institute /ID# 218998
Boston, Massachusetts, United States
University of Michigan /ID# 218463
Ann Arbor, Michigan, United States
Henry Ford Hospital /ID# 221190
Detroit, Michigan, United States
William Beaumont Hospital /ID# 222705
Royal Oak, Michigan, United States
Saint Louis University Cancer Center /ID# 222287
St Louis, Missouri, United States
Summit Medical Group-Florham Park /ID# 222620
Florham Park, New Jersey, United States
Hackensack Univ Med Ctr /ID# 219047
Hackensack, New Jersey, United States
The Cancer Institute at St. Francis Hospital /ID# 231782
Greenvale, New York, United States
Manhattan Hematology Oncology MHO Associates /ID# 223193
New York, New York, United States
Memorial Sloan Kettering Cancer Center-Koch Center /ID# 221081
New York, New York, United States
Atrium Health Wake Forest Baptist Medical Center /ID# 222899
Winston-Salem, North Carolina, United States
MetroHealth Medical Center /ID# 222650
Cleveland, Ohio, United States
Pennsylvania Cancer Specialists & Research Institute /ID# 271376
Gettysburg, Pennsylvania, United States
Hospital of the University of Pennsylvania /ID# 219001
Philadelphia, Pennsylvania, United States
Fox Chase Cancer Center /ID# 223955
Philadelphia, Pennsylvania, United States
Texas Oncology - Abilene - Antilley Road /ID# 271379
Abilene, Texas, United States
Duplicate_Houston Methodist Hospital /ID# 223103
Houston, Texas, United States
University of Texas Health San Antonio MD Anderson Cancer Center /ID# 233942
San Antonio, Texas, United States
Utah Cancer Specialists Salt Lake Clinic /ID# 221962
Salt Lake City, Utah, United States
Virginia Cancer Specialists - Fairfax /ID# 223016
Fairfax, Virginia, United States
Providence Everett /ID# 223130
Everett, Washington, United States
Yakima Valley Memorial Hosp /ID# 224368
Yakima, Washington, United States
HSHS St. Vincent Hospital /ID# 224468
Green Bay, Wisconsin, United States
The Kinghorn Cancer Centre /ID# 221097
Darlinghurst, New South Wales, Australia
Border Medical Oncology Research Unit Albury Wodonga Regiona /ID# 223848
East Albury, New South Wales, Australia
Calvary Mater Newcastle /ID# 224324
Waratah, New South Wales, Australia
The Alfred Hospital /ID# 221096
Melbourne, Victoria, Australia
Royal Perth Hospital /ID# 221099
Perth, Western Australia, Australia
Universitaetsklinikum St. Poelten /ID# 221709
Sankt Pölten, Lower Austria, Austria
Medizinische Universitaet Graz /ID# 220919
Graz, Styria, Austria
Ordensklinikum Linz GmbH Elisabethinen /ID# 220914
Linz, Upper Austria, Austria
Klinikum Wels-Grieskirchen GmbH /ID# 220915
Wels, Upper Austria, Austria
Medizinische Universitaet Wien /ID# 220911
Vienna, Vienna, Austria
Hanusch Krankenhaus /ID# 220912
Vienna, Austria
ZAS Cadix /ID# 221468
Antwerp, Antwerpen, Belgium
Cliniques Universitaires UCL Saint-Luc /ID# 224221
Brussels, Brussels Capital, Belgium
Grand Hôpital de Charleroi - Les Viviers /ID# 224827
Charleroi, Hainaut, Belgium
UZ Gent /ID# 220841
Ghent, Oost-Vlaanderen, Belgium
Vitaz /Id# 228150
Sint-Niklaas, Oost-Vlaanderen, Belgium
AZ-Delta /ID# 221469
Roeselare, West-Vlaanderen, Belgium
UMHAT Alexandrovska EAD /ID# 231652
Sofiya, Sofia, Bulgaria
UMHAT Dr Georgi Stranski EAD /ID# 231650
Pleven, Bulgaria
Acibadem City Clinic Tokuda University Hospital EAD /ID# 231649
Sofia, Bulgaria
UMHAT Sveti Ivan Rilski /ID# 231651
Sofia, Bulgaria
UMHAT Sveta Marina /ID# 234119
Varna, Bulgaria
Juravinski Cancer Centre /ID# 220887
Hamilton, Ontario, Canada
Ottawa Hospital Research Institute /ID# 238858
Ottawa, Ontario, Canada
University Health Network_Princess Margaret Cancer Centre /ID# 253942
Toronto, Ontario, Canada
CISSS-CA (Centre Integre de sante et de services sociaux de Chaudiere-Appalache) /ID# 222433
Lévis, Quebec, Canada
McGill University Health Centre - Glen Site /ID# 222614
Montreal, Quebec, Canada
CHUQ- Hôpital de l'Enfant-Jesus /ID# 220888
Québec, Quebec, Canada
Clinical Hospital Dubrava /ID# 230801
Zagreb, City of Zagreb, Croatia
Klinicka bolnica Merkur /ID# 230799
Zagreb, City of Zagreb, Croatia
Klinicki bolnicki centar Zagreb /ID# 230798
Zagreb, City of Zagreb, Croatia
Klinicki bolnicki centar Osijek /ID# 231503
Osijek, County of Osijek-Baranja, Croatia
Klinicki Bolnicki Centar (KBC) Split /ID# 230800
Split, Split-Dalmatia County, Croatia
Fakultní Nemocnice Brno - Jihlavská /ID# 220959
Brno, Brno-mesto, Czechia
Vseobecna fakultni nemocnice v Praze /ID# 220969
Prague, Czechia
Aalborg University Hospital /ID# 224391
Aalborg, North Denmark, Denmark
Roskilde Sygehus /ID# 224456
Roskilde, Region Sjælland, Denmark
Duplicate_CHU DE NICE-HOPITAL LARCHET II /ID# 256291
Nice, Alpes-Maritimes, France
CHU NIMES - Hopital Caremeau /ID# 219128
Nîmes, Gard, France
Centre Hospitalier Universitaire de Bordeaux /ID# 222696
Pessac, Gironde, France
CHU de Nantes, Hotel Dieu -HME /ID# 219127
Nantes, Pays de la Loire Region, France
HCL - Hopital Lyon Sud /ID# 222695
Pierre-Bénite, Rhone, France
Centre Hospitalier Métropole Savoie - Site Hôpital de Chambéry /ID# 223771
Chambéry, Savoie, France
Chu Angers /Id# 219129
Angers, France
Hôpital Saint-Louis /ID# 221390
Paris, France
Hopital Avicenne - APHP /ID# 221287
Bobigny, Île-de-France Region, France
Universitatsklinikum Mannheim /ID# 221529
Mannheim, Baden-Wurttemberg, Germany
Stauferklinikum Schwaebisch Gmuend /ID# 223948
Mutlangen, Baden-Wurttemberg, Germany
Gemeinschaftspraxis Dr. Heinrich und Prof. Bangerter /ID# 225025
Augsburg, Bavaria, Germany
Universitaetsmedizin Rostock /ID# 224157
Rostock, Mecklenburg-Vorpommern, Germany
Augusta-Kranken-Anstalt gGmbH, Bochum-Mitte /ID# 224695
Bochum, North Rhine-Westphalia, Germany
Klinikum Chemnitz gGmbH /ID# 224575
Chemnitz, Saxony, Germany
BAG Freiberg-Richter, Jacobasch, Illmer, Wolf /ID# 221346
Dresden, Saxony, Germany
OncoResearch Lerchenfeld GmbH /ID# 225034
Hamburg, Germany
Klinikum rechts der Isar /ID# 221526
Munich, Germany
Olympion General Clinic /ID# 261423
Pátrai, Achaia, Greece
General Hospital of Athens Laiko /ID# 221175
Athens, Attica, Greece
General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 221179
Athens, Greece
University General Hospital of Patras /ID# 221178
RION Patras Achaia, Greece
General Hospital of Thessaloniki George Papanikolaou /ID# 221463
Thessaloniki, Greece
Fejér Vármegyei Szent György Egyetemi Oktató Kórház /ID# 220949
Székesfehérvár, Fejér, Hungary
Debreceni Egyetem-Klinikai Kozpont /ID# 220947
Debrecen, Hajdú-Bihar, Hungary
Somogy Varmegyei Kaposi Mor Oktato Korhaz /ID# 220948
Kaposvár, Somogy County, Hungary
Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz /ID# 220946
Nyíregyháza, Szabolcs-Szatmár-Bereg, Hungary
Szegedi Tudományegyetem /ID# 220955
Szeged, Hungary
Yitzhak Shamir Medical Center /ID# 222972
Ẕerifin, Central District, Israel
HaEmek Medical Center /ID# 220839
Afula, H_efa, Israel
Rambam Health Care Campus /ID# 219121
Haifa, H_efa, Israel
The Lady Davis Carmel Medical Center /ID# 222973
Haifa, H_efa, Israel
Hadassah Medical Center-Hebrew University /ID# 219111
Jerusalem, Jerusalem, Israel
Hadassah Mt. Scopus /ID# 253394
Jerusalem, Jerusalem, Israel
Galilee Medical Center /ID# 225280
Nahariya, Northern District, Israel
Duplicate_Assuta Ashdod Medical Center /ID# 225281
Ashdod, Southern District, Israel
The Chaim Sheba Medical Center /ID# 219136
Ramat Gan, Tel Aviv, Israel
Tel Aviv Sourasky Medical Center /ID# 219135
Tel Aviv, Tel Aviv, Israel
Rabin Medical Center /ID# 219139
Petah Tikva, Israel
Duplicate_IRCCS AOU di Bologna - Policlinico Sant'Orsola-Malpighi /ID# 221077
Bologna, Emilia-Romagna, Italy
Azienda Ospedaliero Universitaria Careggi /ID# 219090
Florence, Firenze, Italy
Duplicate_Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Universita /ID# 219087
Rome, Lazio, Italy
Fondazione IRCCS San Gerardo dei Tintori - Ospedale San Gerardo /ID# 225113
Monza, Monza E Brianza, Italy
Azienda Ospedaliera Universitaria Federico II /ID# 224673
Naples, Napoli, Italy
A.O.U. CITTA' DELLA SALUTE E DELLA SCIENZA DI TORINO - Ospedale Molinette /ID# 221223
Turin, Piedmont, Italy
Azienda Ospedaliero-Universitaria Policlinico Umberto I /ID# 225731
Rome, Roma, Italy
Azienda Ospedaliero Universitaria delle Marche /ID# 238438
Ancona, Italy
ASST Papa Giovanni XXIII /ID# 221222
Bergamo, Italy
AOU Policlinico G. Rodolico - San Marco /ID# 219089
Catania, Italy
Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone /ID# 221078
Palermo, Italy
Grande Ospedale Metropolitano Bianchi - Melacrino - Morelli P.O. Riuniti /ID# 221220
Reggio Calabria, Italy
Duplicate_University Hospital Santa Maria della Misericordia /ID# 221241
Udine, Italy
ASST Sette Laghi - Ospedale Di Circolo E Fondazione Macchi Varese /ID# 234183
Varese, Italy
Azienda ULSS 8 Berica /ID# 221079
Vicenza, Italy
Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital /ID# 221150
Nagoya, Aichi-ken, Japan
Fujita Health University Hospital /ID# 221598
Toyoake, Aichi-ken, Japan
Aomori Prefectural Central Hospital /ID# 221778
Aomori, Aomori, Japan
Chiba University Hospital /ID# 224546
Chiba, Chiba, Japan
National Cancer Center Hospital East /ID# 226653
Kashiwa-shi, Chiba, Japan
Ehime University Hospital /ID# 221158
Toon-shi, Ehime, Japan
Kyushu University Hospital /ID# 221606
Fukuoka, Fukuoka, Japan
Fukushima Medical University Hospital /ID# 221877
Fukushima, Fukushima, Japan
Gifu University Hospital /ID# 224371
Gifu, Gifu, Japan
Sapporo Hokuyu Hospital /ID# 221149
Sapporo, Hokkaido, Japan
Kobe City Medical Center General Hospital /ID# 221156
Kobe, Hyōgo, Japan
Kanazawa University Hospital /ID# 223028
Kanazawa, Ishikawa-ken, Japan
Iwate Medical University Hospital /ID# 222044
Shiwa-gun, Iwate, Japan
Shonan Kamakura General Hospital /ID# 223030
Kamakura-shi, Kanagawa, Japan
Kumamoto Shinto General Hospital /ID# 255645
Kumamoto, Kumamoto, Japan
Kyoto University Hospital /ID# 223008
Kyoto, Kyoto, Japan
Mie University Hospital /ID# 221665
Tsu, Mie-ken, Japan
University of Miyazaki Hospital /ID# 221821
Miyazaki, Miyazaki, Japan
Niigata University Medical & Dental Hospital /ID# 223034
Niigata, Niigata, Japan
Kurashiki Central Hospital /ID# 221690
Kurashiki-shi, Okayama-ken, Japan
Kansai Medical University Hospital /ID# 257289
Hirakata-shi, Osaka, Japan
The University of Osaka Hospital /ID# 221159
Suita-shi, Osaka, Japan
Dokkyo Medical University Saitama Medical Center /ID# 222334
Koshigaya, Saitama, Japan
Juntendo University Shizuoka Hospital /ID# 221780
Izunokuni-shi, Shizuoka, Japan
Juntendo University Hospital /ID# 221154
Bunkyo-ku, Tokyo, Japan
Nippon Medical School Hospital /ID# 221676
Bunkyo-ku, Tokyo, Japan
Tokyo Medical University Hospital /ID# 221540
Shinjuku-ku, Tokyo, Japan
Tokyo Metropolitan Bokutoh Hospital /ID# 254774
Sumida-ku, Tokyo, Japan
University of Yamanashi Hospital /ID# 221706
Chuo-shi, Yamanashi, Japan
IMSUT Hospital, The Institute of Medical Science, The University of Tokyo /ID# 257944
Tokyo, Japan
Aotearoa Clinical Trials /ID# 232201
Papatoetoe, Auckland, New Zealand
ARS-MEDICAL Sp. z o.o. /ID# 238336
Piła, Greater Poland Voivodeship, Poland
Szpital Kliniczny im. Heliodora Swiecickiego Uniwersytetu Medycznego im. Karola /ID# 241031
Poznan, Greater Poland Voivodeship, Poland
SP ZOZ Szpital Uniwersytecki w Krakowie /ID# 221160
Krakow, Lesser Poland Voivodeship, Poland
Uniwersytecki Szpital Kliniczny Nr 1 w Lublinie /ID# 221124
Lublin, Lublin Voivodeship, Poland
Lux Med Onkologia - Szpital Szamocka /Id# 221265
Warsaw, Masovian Voivodeship, Poland
MTZ Clinical Research Powered by Pratia /ID# 221759
Warsaw, Masovian Voivodeship, Poland
Uniwersyteckie Centrum Kliniczne /ID# 221298
Gdansk, Pomeranian Voivodeship, Poland
Pratia Onkologia Katowice /ID# 224526
Katowice, Poland
Wojewódzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopern /ID# 221161
Lodz, Łódź Voivodeship, Poland
Hospital del Centro Comprensivo de Cancer de la UPR /ID# 223281
San Juan, Puerto Rico
Moscow State budget healthcare /ID# 221116
Moscow, Moscow, Russia
Clinic UZI 4D /ID# 221303
Pyatigorsk, Stavropol Kray, Russia
Hospital n.a. V.V. Veresaev /ID# 225221
Moscow, Russia
Russian Research Institute of Hematology and Transfusiology of the FMBA /ID# 221115
Saint Petersburg, Russia
Almazov National Medical Research Centre /ID# 221114
Saint Petersburg, Russia
Tula Regional Clinical Hospital /ID# 221302
Tula, Russia
University Clinical Center Serbia /ID# 231058
Belgrade, Beograd, Serbia
Clin Hosp Ctr Bezanijska Kosa /ID# 231059
Belgrade, Beograd, Serbia
University Clinical Center Vojvodina /ID# 231057
Novi Sad, Serbia
Duplicate_Wits Clinical Research Site /ID# 231554
Johannesburg, Gauteng, South Africa
Alberts Cellular Therapy /ID# 231556
Pretoria, Gauteng, South Africa
Pusan National University Hospital /ID# 220980
Busan, Busan Gwang Yeogsi, South Korea
Gachon University Gil Medical Center /ID# 220972
Incheon, Gyeonggido, South Korea
Seoul National University Hospital /ID# 219060
Seoul, Seoul Teugbyeolsi, South Korea
Samsung Medical Center /ID# 221091
Seoul, Seoul Teugbyeolsi, South Korea
The Catholic University of Korea, Seoul St. Marys Hospital /ID# 219061
Seoul, Seoul Teugbyeolsi, South Korea
Complejo Hospitalario Universitario A Coruña /ID# 224617
A Coruña, A Coruna, Spain
Duplicate_Hospital Clínico Universitario de Santiago-CHUS /ID# 221616
Santiago de Compostela, A Coruna, Spain
Hospital Universitario Germans Trias i Pujol /ID# 233727
Badalona, Barcelona, Spain
Hospital Universitario Dr. Negrin /ID# 220923
Las Palmas de Gran Canaria, Las Palmas, Spain
Hospital Universitario Central de Asturias /ID# 224815
Oviedo, Principality of Asturias, Spain
Hospital Parc de Salut del Mar /ID# 220922
Barcelona, Spain
Hospital Universitario Vall d'Hebron /ID# 240979
Barcelona, Spain
Hospital Universitario Virgen de las Nieves /ID# 253936
Granada, Spain
Hospital Universitario 12 de Octubre /ID# 233726
Madrid, Spain
Hospital Universitario La Paz /ID# 224813
Madrid, Spain
Hospital Regional Universitario de Malaga /ID# 221906
Málaga, Spain
Hospital Universitario de Salamanca /ID# 221904
Salamanca, Spain
Hospital Universitario Virgen del Rocio /ID# 221932
Seville, Spain
Hospital Clinico Universitario de Valencia /ID# 220920
Valencia, Spain
Skane University Hospital Lund /ID# 220834
Lund, Skåne County, Sweden
Duplicate_Universitätsspital Basel /ID# 221261
Basel, Canton of Basel-City, Switzerland
Inselspital, Universitaetsspital Bern /ID# 223439
Bern, Switzerland
Kaohsiung Chang Gung Memorial Hospital /ID# 218985
Kaohsiung City, Kaohsiung, Taiwan
Chi Mei Hospital - Liouying /ID# 221144
Tainan, Tainan, Taiwan
National Taiwan University Hospital /ID# 271207
Taipei City, Taipei, Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 218980
Kaohsiung City, Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 271389
Kaohsiung City, Taiwan
China Medical University Hospital /ID# 218979
Taichung, Taiwan
National Cheng Kung University Hospital /ID# 271206
Tainan, Taiwan
Taipei Veterans General Hosp /ID# 221147
Taipei, Taiwan
Linkou Chang Gung Memorial Hospital /ID# 218982
Taoyuan, Taiwan
Medipol Mega Üniversite Hastanesi /ID# 271374
Tuzla, Istanbul, Turkey (Türkiye)
Gulhane Askeri Tip Academy /ID# 224568
Ankara, Turkey (Türkiye)
Hacettepe Universitesi Hastaneleri /ID# 271084
Ankara, Turkey (Türkiye)
Trakya University Medical Facu /ID# 224572
Edirne, Istanbul, Turkey (Türkiye)
Ege University Medical Faculty /ID# 224570
Izmir, Turkey (Türkiye)
Mersin University Medical /ID# 224571
Mersin, Turkey (Türkiye)
Ondokuz mayis University Facul /ID# 224567
Samsun, Turkey (Türkiye)
Feofaniya Clinical Hospital of State Management of Affairs /ID# 271397
Kyiv, Ukraine
Dup_Guys and St Thomas NHS Foundation Trust - Guy's Hospital /ID# 221041
London, Greater London, United Kingdom
United Lincolnshire Hospitals NHS Trust /ID# 224613
Lincoln, Lincolnshire, United Kingdom
James Paget University Hospitals NHS Foundation Trust /ID# 221219
Great Yarmouth, Norfolk, United Kingdom
University Hospitals Birmingham NHS Foundation Trust /ID# 221334
Birmingham, United Kingdom
NHS Lothian /ID# 224378
Edinburgh, United Kingdom
The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 221335
Newcastle upon Tyne, United Kingdom