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Everyday Memory Impairment in PD-related Cognitive Decline
Sponsor: Washington University School of Medicine
Summary
The investigators will aim enroll participants into our study within 3-6 months after their parent study visit so the investigators can utilize some key data points (e.g. PD-MCI diagnosis, rs-fcMRI data) from that study. PD participants will participate in a single-blind RCT with two treatment arms: process training and strategy training (Fig 4). They will complete pre-training assessment (Pre), be randomized to treatment arm (1:1 ratio stratified by sex), and then complete 8 training sessions over an 8-week period. They will return within 1 week for post-training assessment (Post) and then will complete Follow-up (FU) assessments via web or mailed survey 3 and 6 months after training ends. They will complete a 12mo FU assessment in person in conjunction with their annual parent study visit. HC participants will complete prospective memory assessment at one time point coinciding with (or within 3-6 months of) their parent study visit to determine whether any relationships observed between rs-fcMRI data and prospective memory are specific to PD.
Official title: Prospective Memory Impairment in Parkinson Disease-related Cognitive Decline: Intervention and Mechanisms
Key Details
Gender
All
Age Range
50 Years - Any
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2021-11-29
Completion Date
2026-09-01
Last Updated
2026-03-18
Healthy Volunteers
No
Interventions
Strategy Training (Time- and Event- Based)
In time-based training, strategic clock-checking behavior is taught by requiring participants to click a button to reveal the virtual time of day. Event-based training involves implementation intention methods.
Locations (1)
Washington University School of Medicine
St Louis, Missouri, United States