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Replacing Protein Via Enteral Nutrition in Critically Ill Patients
Sponsor: King Abdullah International Medical Research Center
Summary
The investigator will investigate the effect of supplemental enteral protein (1.2 g/kg/day) added to standard formula to achieve high amount of enteral protein (range 2-2.4 g/kg/day) given from ICU day 5 until ICU discharge up to ICU day 90 as compared to no supplemental enteral protein to achieve moderate amount enteral protein (0.8-1.2 g/kg/day), given in conjunction with similar amounts of stepwise caloric administration in the two groups on all-cause 90-day mortality.
Official title: Replacing Protein Via Enteral Nutrition in a Stepwise Approach in Critically Ill Patients: An International, Multicenter Randomized Controlled Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
2502
Start Date
2020-09-21
Completion Date
2026-04-30
Last Updated
2025-09-08
Healthy Volunteers
Yes
Conditions
Interventions
Replenish protein group
For patients with Body mass index(BMI) \<30, use pre-ICU actual body weight(BW) for the calculation; if unavailable, use weight on ICU admission. For patients with BMI \>=30, use adjusted body weight
Standard protein group
For patients with BMI \<30, use pre-ICU actual BW for the calculation; if unavailable, use weight on ICU admission. For patients with BMI \>=30, use adjusted body weight
Locations (2)
King Abdulaziz Medical city
Jeddah, Jeddah, Saudi Arabia
Intensive Care Unit, King Abdulaziz Medical City
Riyadh, Saudi Arabia