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Advanced Translational Research on Childhood Leukemia
Sponsor: Chinese University of Hong Kong
Summary
Prognosis of children with leukemia, the most common pediatric cancer, has improved markedly. Yet, relapse still occurs in 15-40% of patients with a probability of survival of \<50%, which is unlikely to be boosted by intensification of standard chemotherapy due to overwhelming toxicity. The advent of effective and safe targeted therapies for high-risk cases is therefore imperative. This study constitutes two research projects aiming at driving therapeutic advances.
Official title: Driving Therapeutic Progress of Childhood Leukemia Through Advanced Translational Research With Immediate and Long-term Impact. Precision Medicine for Childhood Leukemia.
Key Details
Gender
All
Age Range
Any - 18 Years
Study Type
OBSERVATIONAL
Enrollment
300
Start Date
2020-07-01
Completion Date
2028-06-01
Last Updated
2026-02-03
Healthy Volunteers
Yes
Conditions
Interventions
RNA-seq
Gene expression and fusion transcripts analysis
whole exon sequencing
Genetic alternation analysis
Cytogenetics test
Remission and relapse are monitored by cytogenetic analyses.
Locations (1)
Hong Kong Children Hospital
Hong Kong, Hksar, China