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Aspirin and Preeclampsia
Sponsor: University of Chicago
Summary
This is a single-center, double-blind, randomized, placebo-controlled clinical trial. Peripartum and postpartum Activin A are significantly elevated in women with preeclampsia. Our hypothesis is that elevated Activin A levels reflect a remediable signal and that reducing postpartum Activin A levels with aspirin therapy will improve (GLS) in preeclamptic patients.
Official title: Aspirin to Prevent Cardiac Dysfunction in Preeclampsia
Key Details
Gender
FEMALE
Age Range
18 Years - 45 Years
Study Type
INTERVENTIONAL
Enrollment
180
Start Date
2021-02-15
Completion Date
2026-12-31
Last Updated
2025-11-10
Healthy Volunteers
No
Conditions
Interventions
Aspirin 81 mg
Subjects in the interventional arm will receive a daily dose of aspirin 81 mg, starting at their baseline visit and to be taken up to their 6-month follow-up visit.
Placebo
Subjects in this group will receive a daily dose of a placebo pill, starting at their baseline visit and to be taken up to their 6-month follow-up visit.
Locations (1)
University of Chicago Hospital
Chicago, Illinois, United States