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Minimal Invasive Axillary Staging and Treatment After Neoadjuvant Systemic Therapy in Node Positive Breast Cancer
Sponsor: Maastricht University Medical Center
Summary
Today, the majority of clinically node positive (cN+) breast cancer patients is treated with neoadjuvant systemic therapy (NST). Axillary staging and treatment after NST in cN+ patients are areas of controversy. Patients with a pathological complete response (pCR) of the axillary lymph nodes are not expected to benefit from axillary lymph node dissection (ALND). Hence, less invasive axillary staging procedures are being introduced to avoid unnecessary ALND. However, evidence supporting the safety of replacing ALND by less invasive techniques in terms of oncologic safety and impact on quality of life (QoL) is lacking.
Official title: Minimal Invasive Axillary Staging and Treatment After Neoadjuvant Systemic Therapy in Node Positive Breast Cancer (MINIMAX): a Dutch Multicenter Observational Study to Gain Insight in Less and More Invasive Axillary Staging and Treatment in Relation to Oncologic Safety and Quality of Life to Develop Evidence-based Guidelines.
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
549
Start Date
2020-07-16
Completion Date
2027-07-01
Last Updated
2022-08-24
Healthy Volunteers
No
Locations (35)
Jeroen Bosch Hospital
's-Hertogenbosch, Netherlands
Northwest Clinics
Alkmaar, Netherlands
The Netherlands Cancer Institute
Amsterdam, Netherlands
Gelre Hospital
Apeldoorn, Netherlands
Rijnstate Hospital
Arnhem, Netherlands
Red Cross Hospital
Beverwijk, Netherlands
Alexander Monro Hospital
Bilthoven, Netherlands
Amphia Hospital
Breda, Netherlands
Van Weel-Bethesda
Dirksland, Netherlands
Slingeland Hospital
Doetinchem, Netherlands
Albert Schweitzer Hospital
Dordrecht, Netherlands
Gelderse Vallei Hospital
Ede, Netherlands
Catharina Hospital
Eindhoven, Netherlands
Máxima Medical Center
Eindhoven, Netherlands
Medisch Spectrum Twente
Enschede, Netherlands
Martini Hospital
Groningen, Netherlands
Saxenburgh Medical Center
Hardenberg, Netherlands
Ziekenhuisgroep Twente
Hengelo, Netherlands
Tergooi Hospital
Hilversum, Netherlands
Spaarne Gasthuis
Hoofddorp, Netherlands
Dijklander Hospital
Hoorn, Netherlands
Medical Center Leeuwarden
Leeuwarden, Netherlands
Leiden University Medical Center
Leiden, Netherlands
Alrijne Hospital
Leiderdorp, Netherlands
Haaglanden Medical Center
Leidschendam, Netherlands
Maastricht University Medical Center
Maastricht, Netherlands
Canisius Wilhelmina Hospital
Nijmegen, Netherlands
Erasmus Medical Center
Rotterdam, Netherlands
Franciscus Gasthuis
Rotterdam, Netherlands
Ikazia Hospital
Rotterdam, Netherlands
Maasstad Hospital
Rotterdam, Netherlands
Spijkenisse Medical Center
Spijkenisse, Netherlands
ZorgSaam Hospital
Terneuzen, Netherlands
Diakonessenhuis
Utrecht, Netherlands
Isala Hospital
Zwolle, Netherlands