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Neurobiological Mechanisms of Stress in Youth With Chronic Widespread Pain
Sponsor: Boston Children's Hospital
Summary
Chronic widespread pain (CWP) is a common chronic pain condition in youth and often associated with significant pain-related and psychosocial impairment. Understanding the neurobiological mechanisms that may underlie pediatric chronic pain and pain-related impairment can inform future treatments to ameliorate patients' suffering, making it a critical area of empirical investigation.
Key Details
Gender
All
Age Range
11 Years - 17 Years
Study Type
INTERVENTIONAL
Enrollment
70
Start Date
2021-11-04
Completion Date
2026-08-31
Last Updated
2026-02-06
Healthy Volunteers
Yes
Interventions
functional Magnetic Resonance Imaging (fMRI)
Participants will undergo a one hour fMRI scan with pain-induction using heat-based QST protocol.
Allostatic Load Composite
All participants will be asked to provide saliva samples to measure cortisol response over time and dehydroepiandrosterone (DHEA) in addition to physiological measurements such as blood pressure/pulse, height/weight, and waist-hip ratio. Measurements will be taken at baseline and 4-month follow-up.
Locations (1)
Boston Children's Hospital
Boston, Massachusetts, United States