Clinical Research Directory

Inclusion Criteria: * Documented or suspected infection either communautary or hospital acquired * Septic shock defined by the need for vasopressor and lactate\>2 mmol/l despite adequate fluid resuscitation (sepsis-3 definition) * Patients under invasive mechanical ventilation * Body core temperature\>38.3°C * Intravenous sedation or opioids * Ongoing antimicrobial treatment and/or intervention for infection source control * Attending physician confirms clinical equipoise without substantial risk if the patient participates in the trial * Informed consent of next of kin/other designated person before inclusion or procedure for inclusion in emergency situation Exclusion Criteria: * Cardiac arrest within previous 7 days * Acute brain injury within previous 7 days * Extensive burns or epidermal necrolysis * \<18 years old * Body core temperature \>41°C * Under legal guardianship * No affiliation with the French health-care system * Pregnancy * Participation in another interventional study with mortality as the primary endpoint * An investigator's decision not to resuscitate * Patient already recruited in the trial