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Study of Trastuzumab Deruxtecan (T-DXd) vs Investigator's Choice Chemotherapy in HER2-low, Hormone Receptor Positive, Metastatic Breast Cancer
Sponsor: AstraZeneca
Summary
This study will evaluate the efficacy, safety and tolerability of trastuzumab deruxtecan compared with investigator's choice chemotherapy in human epidermal growth factor receptor (HER)2-low, hormone receptor (HR) positive breast cancer patients whose disease has progressed on endocrine therapy in the metastatic setting.
Official title: A Phase 3, Randomized, Multi-center, Open-label Study of Trastuzumab Deruxtecan (T-DXd) Versus Investigator's Choice Chemotherapy in HER2-Low, Hormone Receptor Positive Breast Cancer Patients Whose Disease Has Progressed on Endocrine Therapy in the Metastatic Setting (DESTINY-Breast06)
Key Details
Gender
All
Age Range
18 Years - 105 Years
Study Type
INTERVENTIONAL
Enrollment
866
Start Date
2020-07-24
Completion Date
2026-06-19
Last Updated
2026-03-04
Healthy Volunteers
No
Conditions
Interventions
Trastuzumab deruxtecan
Trastuzumab deruxtecan by intravenous infusion
Capecitabine
Investigator's choice standard of care single agent chemotherapy; capecitabine tablets will be given orally.
Paclitaxel
Investigator's choice standard of care single agent chemotherapy; paclitaxel by intravenous infusion.
Nab-Paclitaxel
Investigator's choice standard of care single agent chemotherapy; nab-paclitaxel by intravenous infusion
Locations (293)
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Scottsdale, Arizona, United States
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Springdale, Arkansas, United States
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Duarte, California, United States
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Los Angeles, California, United States
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Aurora, Colorado, United States
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Lakewood, Colorado, United States
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Washington D.C., District of Columbia, United States
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Jacksonville, Florida, United States
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Kansas City, Kansas, United States
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Louisville, Kentucky, United States
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Bethesda, Maryland, United States
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Boston, Massachusetts, United States
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Detroit, Michigan, United States
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Rochester, Minnesota, United States
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St Louis, Missouri, United States
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Summit, New Jersey, United States
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Westbury, New York, United States
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Columbus, Ohio, United States
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Pittsburgh, Pennsylvania, United States
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Nashville, Tennessee, United States
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Austin, Texas, United States
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Dallas, Texas, United States
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Houston, Texas, United States
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Houston, Texas, United States
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Norfolk, Virginia, United States
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Seattle, Washington, United States
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Madison, Wisconsin, United States
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Buenos Aires, Argentina
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CABA, Argentina
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CABA, Argentina
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CABA, Argentina
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Ciudad de Buenos Aires, Argentina
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Córdoba, Argentina
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La Plata, Argentina
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Mar del Plata, Argentina
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Rosario, Argentina
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Rosario, Argentina
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Adelaide, Australia
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Birtinya, Australia
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Darlinghurst, Australia
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Murdoch, Australia
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South Brisbane, Australia
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St Leonards, Australia
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Waratah, Australia
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Graz, Austria
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Innsbruck, Austria
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Anderlecht, Belgium
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Brussels, Belgium
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Charleroi, Belgium
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Edegem, Belgium
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Ghent, Belgium
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Leuven, Belgium
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Liège, Belgium
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Namur, Belgium
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Roeselare, Belgium
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Sint-Niklaas, Belgium
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Barretos, Brazil
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Belo Horizonte, Brazil
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Natal, Brazil
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Porto Alegre, Brazil
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Porto Alegre, Brazil
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Rio de Janeiro, Brazil
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São Paulo, Brazil
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São Paulo, Brazil
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Sorocaba, Brazil
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Calgary, Alberta, Canada
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Edmonton, Alberta, Canada
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Vancouver, British Columbia, Canada
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Toronto, CA, Canada
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London, Ontario, Canada
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Toronto, Ontario, Canada
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Toronto, Ontario, Canada
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Montreal, Quebec, Canada
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Montreal, Quebec, Canada
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Sherbrooke, Quebec, Canada
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Baoding, China
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Beijing, China
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Beijing, China
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Changchun, China
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Changsha, China
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Changsha, China
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Dalian, China
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Foshan, China
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Fuzhou, China
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Guangzhou, China
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Guangzhou, China
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Guangzhou, China
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Hangzhou, China
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Hangzhou, China
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Hangzhou, China
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Harbin, China
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Hefei, China
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Jinan, China
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Linyi, China
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Nanchang, China
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Nanchang, China
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Nanjing, China
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Nanjing, China
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Nanning, China
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Shanghai, China
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Shenyang, China
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Tianjin, China
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Ürümqi, China
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Wuhan, China
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Xi'an, China
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Xi'an, China
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Zhengzhou, China
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Aalborg, Denmark
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Copenhagen Ø, Denmark
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Odense, Denmark
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Vejle, Denmark
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Avignon, France
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Besançon, France
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Bordeaux, France
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Brest, France
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Caen, France
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Dijon, France
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Le Mans, France
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Marseille, France
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Montpellier, France
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Nice, France
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Paris, France
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Pierre-Bénite, France
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Plerin SUR MER, France
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Rennes, France
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Saint-Cloud, France
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Saint-Herblain, France
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Tours, France
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Villejuif, France
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Berlin, Germany
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Dresden, Germany
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Freiburg im Breisgau, Germany
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Hanover, Germany
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München, Germany
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München, Germany
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Münster, Germany
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Velbert, Germany
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Budapest, Hungary
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Budapest, Hungary
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Budapest, Hungary
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Győr, Hungary
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Kecskemét, Hungary
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Nyíregyháza, Hungary
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Szolnok, Hungary
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Tatabánya, Hungary
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Bengaluru, India
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Calicut, India
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Kolkata, India
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Marg Jaipur, India
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New Delhi, India
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New Delhi, India
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New Delhi, India
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New Delhi, India
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Surat, India
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Thiruvananthapuram, India
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Haifa, Israel
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Jerusalem, Israel
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Jerusalem, Israel
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Kfar Saba, Israel
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Petah Tikva, Israel
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Ramat Gan, Israel
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Tel Aviv, Israel
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Aviano, Italy
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Bergamo, Italy
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Candiolo, Italy
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Cona, Italy
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Genova, Italy
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Livorno, Italy
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Messina, Italy
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Milan, Italy
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Milan, Italy
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Naples, Italy
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Padova, Italy
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Parma, Italy
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Prato, Italy
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Tricase, Lecce, Italy
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Udine, Italy
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Akashi-shi, Japan
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Bunkyō City, Japan
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Chiba, Japan
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Chūōku, Japan
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Fukuoka, Japan
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Gifu, Japan
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Hidaka-shi, Japan
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Hiroshima, Japan
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Isehara, Japan
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Kagoshima, Japan
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Kashiwa, Japan
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Kawasaki-shi, Japan
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Kitaadachi-gun, Japan
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Kōtoku, Japan
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Matsuyama, Japan
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Nagoya, Japan
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Naha, Japan
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Niigata, Japan
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Nishinomiya-shi, Japan
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Okayama, Japan
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Osaka, Japan
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Osakasayama-shi, Japan
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Sagamihara-shi, Japan
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Sapporo, Japan
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Shinagawa-ku, Japan
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Shinjuku-ku, Japan
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Shizuoka, Japan
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Tsu, Japan
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Yokohama, Japan
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Alc. Cuauhtémoc, Mexico
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Guadalajara Jalisco, Mexico
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Guadalajra, Mexico
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Mexico City, Mexico
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Mexico City, Mexico
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Mexico City, Mexico
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México, Mexico
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Monterrey, Mexico
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Nuevo León, Mexico
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Amsterdam, Netherlands
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Breda, Netherlands
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Hengelo, Netherlands
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Leeuwarden, Netherlands
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Rotterdam, Netherlands
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Sittard-Geleen, Netherlands
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Bydgoszcz, Poland
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Koszalin, Poland
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Krakow, Poland
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Lodz, Poland
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Rzeszów, Poland
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Warsaw, Poland
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Wroclaw, Poland
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Lisbon, Portugal
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Lisbon, Portugal
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Lisbon, Portugal
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Krasnodar, Russia
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Moscow, Russia
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Moscow, Russia
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Moscow, Russia
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Moscow, Russia
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Saint Petersburg, Russia
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Saint Petersburg, Russia
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Saint Petersburg, Russia
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Yaroslavl, Russia
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Dammam, Saudi Arabia
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Jeddah, Saudi Arabia
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Jeddah, Saudi Arabia
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Riyadh, Saudi Arabia
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Riyadh, Saudi Arabia
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Riyadh, Saudi Arabia
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Bukit Merah, Singapore
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Singapore, Singapore
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Singapore, Singapore
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Singapore, Singapore
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Singapore, Singapore
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Daegu, South Korea
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Goyang-si, South Korea
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Incheon, South Korea
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Seongnam-si, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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A Coruña, Spain
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Barcelona, Spain
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Barcelona, Spain
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Barcelona, Spain
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Córdoba, Spain
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El Palmar, Spain
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Madrid, Spain
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Madrid, Spain
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Madrid, Spain
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San Sebastián, Spain
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Seville, Spain
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Valencia, Spain
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Gothenburg, Sweden
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Örebro, Sweden
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Stockholm, Sweden
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Uppsala, Sweden
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Vaxjo, Sweden
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Taichung, Taiwan
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Tainan, Taiwan
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Tainan, Taiwan
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Taipei, Taiwan
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Taipei, Taiwan
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Taipei, Taiwan
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Taipei, Taiwan
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Taoyuan District, Taiwan
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Cambridge, United Kingdom
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Cardiff, United Kingdom
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Edinburgh, United Kingdom
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Guildford, United Kingdom
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Leeds, United Kingdom
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London, United Kingdom
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Manchester, United Kingdom
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Northwood, United Kingdom