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RECRUITING
NCT04499859
PHASE4

Low Dose Rosuvastatin Plus Ezetimibe Versus High-dose Rosuvastatin in AMI

Sponsor: Kiyuk Chang, MD,PhD

View on ClinicalTrials.gov

Summary

Combination therapy of rosuvastatin 5mg and ezetimibe 10 mg showed similar achievement rate in decreasing LDL cholesterol level by 50% as single use of rosuvastatin 20 mg. This trial aims to prove non-inferiority of concomitant usage of low dose rosuvastatin and ezetimibe among patients with acute myocardial infarction who went through percutaneous coronary intervention at decreasing major adverse cardiac events compared to the efficacy of single use of high dose rosuvastatin.

Official title: A Prospective, Multicenter, Randomized, Open-label Trial to Compare Low-dose ROSUvastatin Plus eZETimibe Versus High-dose Rosuvastatin in Patients With Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention

Key Details

Gender

All

Age Range

19 Years - Any

Study Type

INTERVENTIONAL

Enrollment

3548

Start Date

2020-10-01

Completion Date

2027-08-30

Last Updated

2025-07-30

Healthy Volunteers

No

Interventions

DRUG

Ezetimibe 10mg + Rosuvastatin 5mg

Initial use of 10mg of ezetimibe combined with 5 mg of rosuvastatin

DRUG

Rosuvastatin 20mg

20mg of Rosuvastatin as a standard treatment for AMI patients

Locations (7)

Bucheon St.Mary Hospital

Bucheon-si, Gyeonggido, South Korea

St.Vincent's Hospital

Suwon, Gyeonggido, South Korea

Uijeongbu St.Mary's Hospital

Uijeongbu-si, Gyeonggido, South Korea

Daejeon St.Mary's Hospital

Daejeon, South Korea

Incheon St.Mary's Hospital

Incheon, South Korea

Seoul St.Mary's Hospital

Seoul, South Korea

Yeouido St.Mary Hospital

Seoul, South Korea