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Low Dose Rosuvastatin Plus Ezetimibe Versus High-dose Rosuvastatin in AMI
Sponsor: Kiyuk Chang, MD,PhD
Summary
Combination therapy of rosuvastatin 5mg and ezetimibe 10 mg showed similar achievement rate in decreasing LDL cholesterol level by 50% as single use of rosuvastatin 20 mg. This trial aims to prove non-inferiority of concomitant usage of low dose rosuvastatin and ezetimibe among patients with acute myocardial infarction who went through percutaneous coronary intervention at decreasing major adverse cardiac events compared to the efficacy of single use of high dose rosuvastatin.
Official title: A Prospective, Multicenter, Randomized, Open-label Trial to Compare Low-dose ROSUvastatin Plus eZETimibe Versus High-dose Rosuvastatin in Patients With Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention
Key Details
Gender
All
Age Range
19 Years - Any
Study Type
INTERVENTIONAL
Enrollment
3548
Start Date
2020-10-01
Completion Date
2027-08-30
Last Updated
2025-07-30
Healthy Volunteers
No
Interventions
Ezetimibe 10mg + Rosuvastatin 5mg
Initial use of 10mg of ezetimibe combined with 5 mg of rosuvastatin
Rosuvastatin 20mg
20mg of Rosuvastatin as a standard treatment for AMI patients
Locations (7)
Bucheon St.Mary Hospital
Bucheon-si, Gyeonggido, South Korea
St.Vincent's Hospital
Suwon, Gyeonggido, South Korea
Uijeongbu St.Mary's Hospital
Uijeongbu-si, Gyeonggido, South Korea
Daejeon St.Mary's Hospital
Daejeon, South Korea
Incheon St.Mary's Hospital
Incheon, South Korea
Seoul St.Mary's Hospital
Seoul, South Korea
Yeouido St.Mary Hospital
Seoul, South Korea