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TO-ChERIsH: Trajectory of Cardiovascular Ageing, Its Determinants and Impact on Health
Sponsor: National Heart Centre Singapore
Summary
Specific Aim 1: To determine longitudinal changes in CV ageing (changes in CV imaging) over time. Hypothesis: There are differences in rates of CV ageing over time. Specific Aim 2: To study determinants of CV ageing To assess how biological pathways affect CV ageing by studying the relationships between biological signatures measured in longitudinal biospecimens are associated with CV ageing. Hypothesis: Antecedent biological markers are associated with progression of CV ageing. Specific Aim 3: To determine the impact of CV ageing progression on the development of clinical CVD and the overall physical, cognitive and functional health of the elderly. Hypothesis: Those with stable CV imaging phenotypes have lower incidence of clinical CVD and also better overall health in ageing, compared to those with rapid deterioration (unhealthy CV ageing).
Key Details
Gender
All
Age Range
21 Years - 100 Years
Study Type
OBSERVATIONAL
Enrollment
500
Start Date
2019-05-13
Completion Date
2049-12
Last Updated
2025-06-05
Healthy Volunteers
Yes
Conditions
Interventions
Examinations
Participants will undergo focused examinations that include measurement of height, weight, waist circumference, body composition analysis, baseline data collection and blood pressure examinations. Resting electrocardiography will be performed to ascertain sinus rhythm.
Cardiovascular Tests
Specific quantitative cardiac ageing-related outcome parameters will be examined by multimodal techniques including two-dimensional transthoracic echocardiogram, and/or non-contrast magnetic resonance imaging/magnetic resonance spectroscopy.
Bio-specimen collection
Bio-specimens collected will include fresh blood, urine and/or stool specimens.
Clinical/health outcome collection
Health status will be tracked by telephone follow-up and/or matching at national disease registries at periodic intervals within one to five years, up to three decades.
Locations (1)
National Heart Centre Singapore
Singapore, Singapore, Singapore