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A Dose Escalation/Expansion Study of Oral OP-1250 in Subjects With Advanced and/or Metastatic HR+, HER2- Breast Cancer
Sponsor: Olema Pharmaceuticals, Inc.
Summary
This clinical trial is a Phase I dose escalation and dose expansion and Phase II monotherapy open-label, first-in-human, multicenter study of OP-1250 in adult subjects with advanced and/or metastatic hormone receptor (HR)-positive, her2-negative breast cancer.
Official title: A Phase I Dose Escalation and Dose Expansion and Phase II Monotherapy Open-label, First-in-Human, Multicenter Study of OP-1250 in Adult Subjects With Advanced and/or Metastatic Hormone Receptor (HR)-Positive, HER2-negative Breast Cancer
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
153
Start Date
2020-08-13
Completion Date
2024-07-30
Last Updated
2026-05-11
Healthy Volunteers
No
Interventions
OP-1250
Complete Estrogen Receptor ANtagonist (CERAN)
Locations (19)
UCLA Hematology/Oncology
Los Angeles, California, United States
University of Colorado
Aurora, Colorado, United States
University of Miami, Sylvester Comprehensive Cancer Center
Deerfield Beach, Florida, United States
Advent Health
Orlando, Florida, United States
Florida Cancer Center
Sarasota, Florida, United States
Winship Cancer Institute of Emory University
Atlanta, Georgia, United States
Indiana University Melvin and Bren Simon Comprehensive Cancer Center
Indianapolis, Indiana, United States
Dana Farber Cancer Institute
Boston, Massachusetts, United States
Saint Luke's Hospital of Kansas City
Kansas City, Missouri, United States
Montefiore Medical Center
The Bronx, New York, United States
Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio, United States
Ohio State University Comprehensive Cancer Center
Columbus, Ohio, United States
Providence Portland Medical Center
Portland, Oregon, United States
OHSU Knight Cancer Institute
Portland, Oregon, United States
Sarah Cannon Research Institute
Nashville, Tennessee, United States
Macquarie University
Sydney, New South Wales, Australia
Westmead
Westmead, New South Wales, Australia
ICON Cancer Centre
Auchenflower, Queensland, Australia
Cancer Research South Australia
Adelaide, South Australia, Australia