Clinical Research Directory

Inclusion Criteria: * Must admit to feeling stressed and/or have PSS score \> 13 (moderate stress) * Must be willing to complete stress reduction course and imaging sessions with \< 3 missed appointments in last year * Known clinical cardiovascular disease with prior atherosclerotic myocardial infarction, percutaneous intervention or bypass surgery \> 6 months before entry, or severe coronary calcifications on computed tomography or coronary calcium score \>400 * Stable symptoms without symptomatic heart failure or arrhythmia or planned revascularization * Maximally tolerated and stable medical regimen for 90 days that does not include a high intensity statin for clinical reasons * No neurological disease or systemic inflammatory disease/current anti-inflammatory therapy * No active psychiatric disease/medications or substance abuse (including tobacco smoking or more than moderate alcohol) for last 6 months * No current participation in cardiac rehab or prior participation in stress reduction * For imaging: no pregnancy, weight \> 300 lbs., metal implants, uncontrolled hyperglycemia, or inability to provide consent or comply