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RECRUITING
NCT04506008
PHASE2

Hypofractionated Radiotherapy Followed by Surgical Resection in the Treatment of Soft Tissue Sarcomas

Sponsor: Vanderbilt-Ingram Cancer Center

View on ClinicalTrials.gov

Summary

The trial will use neoadjuvant hypofractionated radiotherapy followed by surgical resection in the treatment for soft tissue sarcoma. It will allow patients to be treated over a shorter course (5 or 15 days of radiation) compared to the traditional 5 week regimen. It is proposed that this will be possible without increasing the risk of wound complication or local recurrence compared with a traditional 5 week course of pre-operative radiation.

Official title: Prospective Observational Trial of Two Neoadjuvant Hypofractionated Radiotherapy Regimens Followed by Surgical Resection in the Treatment of Soft Tissue Sarcomas

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

40

Start Date

2021-03-02

Completion Date

2027-06

Last Updated

2025-03-28

Healthy Volunteers

No

Interventions

RADIATION

Ultra-Hypo-fractionation Radiotherapy

Five fractions of pre-operative radiation

PROCEDURE

Resection

Surgery

OTHER

Questionnaire Administration

Ancillary studies

RADIATION

Moderately-Hypo-fractionation Radiotherapy

15 fractions of pre-operative radiation

Locations (1)

Vanderbilt-Ingram Cancer Center

Nashville, Tennessee, United States