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Cardiac Rehab Effects in HFpEF
Sponsor: VA Office of Research and Development
Summary
This research in Veterans with heart failure with preserved ejection fraction (HFpEF) will provide new information on the mechanisms determining the patients' exercise intolerance and the efficacy of regular physical activity to improve this shortcoming by alleviating the patients' neurocirculatory abnormalities. Specifically, the investigators will focus on the role of nerves originating in working limb muscles in determining the patients' exercise intolerance and compromised fatigue resistance before and after a chronic exercise intervention. By focusing on a specific mechanism, this project will evaluate the validity of exercise as an alternative treatment strategy with the overall purpose of improving the quality of life of Veterans with HFpEF.
Official title: Efficacy of Exercise Training in Patients With HFpEF
Key Details
Gender
All
Age Range
21 Years - 85 Years
Study Type
INTERVENTIONAL
Enrollment
45
Start Date
2022-05-02
Completion Date
2026-09-30
Last Updated
2026-03-19
Healthy Volunteers
Yes
Interventions
Afferent block
Block sensory feedback to evaluate hemodynamic and fatigue consequence of group III/IV muscle afferents
Locations (1)
VA Salt Lake City Health Care System, Salt Lake City, UT
Salt Lake City, Utah, United States