Inclusion Criteria:
* Histologically confirmed invasive breast carcinoma with a primary tumor size of more than (\>) 2 centimeters (cm) by standard local assessment technique；
* Breast cancer stage at presentation: early-stage (T2-3, N0-1, M0), locally advanced (T2-3, N2-3,M0 or T4a-c, any N, M0), or infl ammatory (T4d, any N,M0)；
* Known hormone receptor status (estrogen receptor and/or progesterone receptor)；
* HER2 positive (HER2+++ by IHC or ISH+).
* Baseline left ventricular ejection fracture \>= 55% measured by echocardiography (preferred) or multiple gated acquisition scan；
* Normalities in liver, kidney or hematologic function laboratory tests immediately prior to randomization;
* Absolute value of neutrophils ≥ 1.5 × 109 / L;
* Platelet ≥ 90×109 / L;
* Hemoglobin ≥ 90g / L;
* Serum creatinine≤ 1.5 times the upper limit of normal (ULN);
* Serum total bilirubin≤1.5 times ULN (except for Gilbert syndrome);
* Aspartate aminotransferase (AST) and / or alanine aminotransferase (ALT) ≤ 1.5-fold ULN;
* International normalized ratio (INR), activated partial prothrombin time (APTT) ≤ 1.5 times ULN.
* ECOG≤1；
Exclusion Criteria:
* Stage IV metastatic ;
* Bilateral breast cancer;
* Previous anti-cancer therapy or radiotherapy for any malignancy;
* History of other malignancy within 5 years, except for appropriately-treated carcinoma in Cervical carcinoma in situ, basal cell carcinoma or squamous cell skin cancer;
* Serious cardiac illness or medical condition;
* HIV antibody positive; HCV antibody positive and HCV RNA positive; HBcAb or HBsAg positive, and HBV DNA positive;
* Sensitivity to any of the study medications, any of the ingredients or excipients of these medications;
* Known mental history had poor compliance;
* Known to have drug abusers;
* Concurrent anti-cancer treatment in another investigational trial, including hormone therapy, bisphosphonate therapy, or immunotherapy;
* Needed intravenous antibiotic treatment due to infection within 7 days before random enrollment;
* Major surgical procedure unrelated to breast cancer within 4 weeks prior to randomization or expected to perform major surgery during the trial period;
* Premenopausal women (menopause is defined as non treatment induced menopause≥12 months) or without surgical sterilization (e.g., ovariectomy and / or uterus): refuse to take one or more effective contraceptive measures during treatment and at least 6 months after the last study treatment; blood pregnancy test is positive; pregnant or lactating women; Considered unsuitable for the study or may not be able to complete the trial due to other reasons.
