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Longitudinal Neuroimaging in Sturge-Weber Syndrome
Sponsor: Wayne State University
Summary
In this project the accuracy of a novel, rapid magnetic resonance imaging (MRI) approach to detect brain abnormalities in patients with Sturge-Weber syndrome (SWS) will be tested; this new imaging approach, that can create multiple types of MR images in about 5 minutes, without contrast administration (and sedation even in young children), can be also readily applied in other pediatric brain disorders in the future. The investigators will also study how advanced MRI, including susceptibility-weighted and diffusion tensor imaging can detect detailed signs of brain vascular and neuronal reorganization that helps improve neurological and cognitive outcome of children and young adults with SWS, who could benefit from targeted interventions in the future to minimize neurocognitive deficits in affected patients. All enrolled subjects will undergo advanced brain MRI and neurocognitive evaluation to achieve these goals.
Key Details
Gender
All
Age Range
3 Months - 30 Years
Study Type
INTERVENTIONAL
Enrollment
80
Start Date
2020-03-01
Completion Date
2026-02-28
Last Updated
2025-07-15
Healthy Volunteers
Yes
Conditions
Interventions
Brain magnetic resonance imaging
Brain magnetic resonance imaging (MRI) will be done using multiple sequences to evaluate presence, type and severity of brain abnormalities in enrolled subjects.
Neuro-psychology testing
Participants will undergo age-appropriate neuro-psychology testing to assess motor, language and other neuro-cognitive functions potentially affected by Sturge-Weber syndrome.
Locations (1)
Wayne State University / Children's Hospital of Michigan
Detroit, Michigan, United States