Clinical Research Directory

Inclusion Criteria: 1. BMI ≥ 30 with at least one of the following, or BMI ≥ 25 with at least two of the following: 1. Untreated Hypertension: Stage I (BP 120-139/80-89 mmHg) or stage II (BP 140-159/90-99 mmHg). 2. Treated Hypertension: On one anti-hypertensive medication with BP\<140/90 mmHg and willing to undergo a 2-week washout of the medication before initiating eplerenone or chlorthalidone + KCl 3. Dysglycemia: Impaired fasting plasma glucose (100-125 mg/dL) or glycated A1c 5.7-6.4% 4. Dyslipidemia: Fasting triglyceride level \> 150 mg/dL and HDL\< 40 mg/dL in men or \<50 mg/dL in women. 2. Age between 18 and 70 years old Exclusion Criteria: * Estimated glomerular filtration rate \< 60 mL/min/1.73m2) * Serum potassium \> 5.2 mEq/L * Known diagnosis or treatment for type 1 or type 2 diabetes * Known history of CVD (myocardial infarction, heart failure, atrial fibrillation, or stroke) * EKG with ischemic ST-segment or T-wave changes or Q waves in more than one territorial lead or a left bundle branch block * Pregnancy (verified with a pregnancy test) or breast-feeding