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Effects of 5HTP on the Injured Human Spinal Cord
Sponsor: University of Alberta
Summary
This study will assess how the serotonin precursor, 5-HTP, alter nervous system excitability and motor function in individuals with spinal cord injuries of differing chronicity and severity. Participants will visit the lab on 4 separate occasions where they will be administered four different drugs in a randomized, double-blinded, placebo-controlled crossover design.
Official title: Effects of the Serotonin Precursor, 5-hydroxytryptophan, in the Injured Human Spinal Cord
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2020-07-01
Completion Date
2026-12-30
Last Updated
2025-08-27
Healthy Volunteers
No
Conditions
Interventions
5-Hydroxytryptophan 100 MG
100mg combined with 50mg carbidopa
5-Hydroxytryptophan
50mg combined with 50mg carbidopa
Carbidopa
50mg
Placebo
Placebo
Locations (2)
University of Louisville
Louisville, Kentucky, United States
University of Alberta
Edmonton, Alberta, Canada