Clinical Research Directory

Inclusion Criteria: * 50 years or older (actual or estimated) * History or evidence of head injury (e.g. laceration, bruise, swelling or pain in head or face) * GCS ≥ 13 * Has one or more of the following: 1. has or had any impaired consciousness (loss of consciousness, amnesia, or confusion) 2. nausea or vomiting * Within 3 hours of injury (do not include if interval cannot be estimated e.g. patient unable to confirm time of fall or patient found on floor after an unwitnessed fall and home alone) * Not living in a nursing home, mental health institution or prison * Patient will be conveyed to or is admitted to a participating hospital Exclusion Criteria: \- TXA not clearly indicated (e.g. major bleeding) or contraindicated (e.g. suspected stroke)