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Impact of Remimazolam on Prognosis After Bladder Cancer Surgery
Sponsor: Peking University First Hospital
Summary
Bladder cancer is one of the most common genitourinary cancers. Transurethral resection of bladder tumor (TURBT) is the standard therapy for nonmuscle invasive bladder cancer. However, patients after TURBT are at risk for recurrence and progression. Benzodiazepines are proved to inhibit proliferation of multiple types of cancer cells in vitro. Delirium is an acute onset and transient cerebral dysfunction and is associated with worse outcomes. Previous studies indicated that benzodiazepines increase incidence of postoperative delirium. Remimazolam is a new benzodiazepine with rapid onset and ultra-short activity. The aims of this study are to explore the impact of remimazolam for general anesthesia on emergency delirium and recurrence-free survival in patients undergoing bladder cancer surgery.
Official title: Impact of Remimazolam Tosilate for General Anesthesia on Prognosis After Bladder Cancer Surgery: a Randomized Controlled Trial
Key Details
Gender
All
Age Range
50 Years - 90 Years
Study Type
INTERVENTIONAL
Enrollment
1128
Start Date
2021-02-05
Completion Date
2026-10
Last Updated
2025-07-30
Healthy Volunteers
No
Interventions
Remimazolam
Remimazolam is administered intravenously for anesthesia induction and maintenance. The dose and infusion rate is adjusted to maintain BIS value between 40 and 60. Analgesia is maintained with remifentanil and/or sufentanil. Muscle relaxation is maintained with rocuronium and/or cisatracurium. Sevoflurane inhalation is provided when considered necessary.
Propofol
Propofol is administered intravenously for anesthesia induction and maintenance. The dose and infusion rate is adjusted to maintain BIS value between 40 and 60. Analgesia is maintained with remifentanil and/or sufentanil. Muscle relaxation is maintained with rocuronium and/or cisatracurium. Sevoflurane is provided when considered necessary.
Locations (6)
Beijing Tsinghua Chang Gung Hospital
Beijing, Beijing Municipality, China
The Sixth Medical Center of PLA General Hospital
Beijing, Beijing Municipality, China
Peking University First Hospital
Beijin, Bejing, China
Guizhou Provincial People's Hospital
Guiyang, Guizhou, China
Jiangsu Provincial People's Hospital
Nanjing, Jiangsu, China
Shanghai 10th People's Hospital
Shanghai, Shanghai Municipality, China