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Genetic Testing in Young Adults With Cancer Study
Sponsor: University of Pennsylvania
Summary
The overarching goal of our research is to define an evidence-based, sustainable approach to identifying and managing genetic risk among young adults with cancer and their relatives. Conventional practice leaves referral and testing decisions to mostly non-expert clinicians implementing complex guidelines at the point of care, leading to substantial under-utilization. The investigators hypothesize that panel-based universal screening coupled with electronic medical record- (EMR-) based algorithms can improve ascertainment of genetic risk by functioning as an automated, radically simplified default practice in place of repeated single decisions requiring clinician cognitive effort and action. A secondary goal is to explore differences in ascertainment of genetic risk among first-degree relatives of probands.
Official title: Randomized Trial of Universal vs. Guideline-directed Germline Testing Among Young Adults With Cancer
Key Details
Gender
All
Age Range
18 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
749
Start Date
2020-12-01
Completion Date
2025-09-26
Last Updated
2026-09-16
Healthy Volunteers
No
Conditions
Interventions
Broad gene panel for young adult cancers
Genetic testing will occur using a broad gene panel for young adult cancers
Standard
Those in the standard group who are considered high risk will have genetic testing done using the standard of care panel as selected by their care provider.
Locations (1)
University of Pennsylvania
Philadelphia, Pennsylvania, United States