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Strategy to Avoid Excessive Oxygen for Critically Ill Trauma Patients
Sponsor: University of Colorado, Denver
Summary
The objective is to determine the effectiveness of a multimodal educational intervention to reduce supplemental oxygen use in critically injured patients. Investigators will also evaluate the safety and clinical effectiveness of the more targeted use of oxygen therapy.
Official title: Strategy to Avoid Excessive Oxygen for Critically Ill Trauma Patients (SAVE-O2)
Key Details
Gender
All
Age Range
18 Years - 120 Years
Study Type
INTERVENTIONAL
Enrollment
6000
Start Date
2020-10-15
Completion Date
2025-06-30
Last Updated
2025-04-02
Healthy Volunteers
No
Interventions
Targeting Normoxemia (SpO2 90-96%; PaO2 60-100 mmHg)
Post-implementation of targeted normoxemia through oxygen titration for individual patients. Interventions for treatment of hypoxemia will follow usual local practice. Interventions for treatment of hyperoxemia (SpO2 \>96% or PaO2 \>100 mmHg) will involve down titration of FiO2 (or supplemental oxygen for non-mechanically ventilated patients) within a time frame based on local site preferences-typically in increments of no greater than 0.10 until goal oxygenation in the normoxemia range is achieved (including room air \[no supplemental oxygen\] for non-mechanically ventilated patients).
Locations (8)
University of Alabama-Birmingham Medical Center
Birmingham, Alabama, United States
Denver Health
Denver, Colorado, United States
University of Cincinnati Medical Center
Cincinnati, Ohio, United States
Oregon Health and Sciences University
Portland, Oregon, United States
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, United States
Vanderbilt University Medical Center
Nashville, Tennessee, United States
Brooke Army Medical Center
Fort Sam Houston, Texas, United States
The University of Texas Health Science Center at Houston
Houston, Texas, United States