Clinical Research Directory

Inclusion Criteria: * Physician-confirmed diagnosis of MS based on the 2017 McDonald criteria * 18-64 years old * Have access to the internet and a device that can access virtual visits * (Inclusion criteria to advance to clinical trial) Somatosensory evoked potential (SSEP) latency z-score ≥2 for P40 or inter-side difference in z-score ≥2 for P40 Exclusion Criteria: * Medical or biophysical conditions that prohibit the use of a cycle ergometer or treadmill (medical readiness to be assessed by the Activity Readiness Questionnaire (PAR-Q)) or achievement of target heart rate. * Engages in \>30 minutes/week of aerobic activity regularly. * Clinically confirmed MS relapse in the last 3 months. * Changes in disease modifying therapy (DMT) for MS in the last 6 months. * Pregnant women. * Treatment with steroids for MS in the last 30 days. * Concurrent use of 4-aminopyridine or dalfampridine (medications which can alter SSEP) and unwilling to discontinue it for 2 days prior to SSEP testing. * Have a known history of severe spinal canal stenosis