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The Nordic Baltic Chronic Total Occlusion (CTO) Arrhythmia Study
Sponsor: Leif Thuesen
Summary
In patients with a chronic total coronary occlusion (CTO ), clinically significant arrhythmia seems to be an important and a poorly investigated problem. The arrhythmia prevalence in an all-comer CTO-population is unknown, but in ICD-populations with ischemic heart disease, a CTO may be found in half of patients with life-threatening arrhythmia.The purpose of the CTO-ARRHYTHMIA study, is to investigate the incidence of clinically significant arrhythmias in CTO patients using an implantable loop recorder. Further, the investigators intend to identify predictors for arrhythmias as well as the impact on arrhythmia of optimized pharmacological treatment and revascularization in CTO patients.
Official title: Chronic Total Coronary Occlusion; Arrhythmia in Patients With Adjunction of PCI to Optimal Medical Treatment Versus Optimal Medical Treatment and in Patients With Failed PCI.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
200
Start Date
2020-11-01
Completion Date
2027-09-01
Last Updated
2026-03-20
Healthy Volunteers
No
Conditions
Interventions
PCI
A loop recorder is implanted i all patients in both study groups to investigate: * Prevalence and severity of cardiac arrhythmias. * Effect on detected arrhythmia, in particular ventricular tachyarrhythmia, of optimal medical therapy vs. coronary revascularization by PCI. * Prevalence and severity of cardiac arrhythmias in CTO-patients with failed PCI. * Indication for prophylactic ICD implantation in CTO-patients treated conservatively or by PCI and after failed PCI. * Relation of arrhythmias to angina pectoris symptoms (CCS class), Quality of life questionnaire results and presence of myocardial reversible perfusion defects by CMRI.
Locations (1)
Aalborg university hospital
Aalborg, North Denmark, Denmark