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The Efficacy of Everolimus With Reduced-dose Tacrolimus Versus Reduced-dose Tacrolimus and Leflunomide in Treatment of BK Virus Infection in Kidney Transplantation Recipient
Sponsor: King Chulalongkorn Memorial Hospital
Summary
BK virus infection is one of the causes of renal allograft loss in the current era. Reduction of immunsuppression is the only intervention that prooved to be effective in treating of BK virus in kidney transplant recipient. However, there are evidences from retrospective and prospective studies showed that leflunomide and mTOR inhibitor such as everolimus or sirolimus have positive outcomes in treatment of BK virus in kidney tranplant recipient. The investigators conduct the RCT to compare the efficacy of leflunomide and mTOR inhibitor everolimus, in treatment of BK virus infected patients who do not respond to immunosuppression reduction.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2021-02-10
Completion Date
2026-07
Last Updated
2025-12-31
Healthy Volunteers
No
Interventions
Everolimus
Everolimus will be given with tacrolimus.
reduced dose tacrolimus and Leflunomide
Reduced dose tacrolimus will be given with leflunomide
Locations (1)
King Chulalongkorn Memorial Hospital
Bangkok, Bangkok, Thailand