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RECRUITING

NCT04543461

American Lung Association (ALA) Lung Health Cohort

Sponsor: Johns Hopkins University

View on ClinicalTrials.gov

Summary

The ALA-LHC is a longitudinal, multi-center cohort study that will enroll approximately 4,000 young adults between the ages of 25-35 who do not have severe lung disease. The overarching objective of the ALA-LHC is to establish a national cohort of young adults for the purpose of defining lung health and developing targets to intercept chronic lung disease at its earliest stages.

Official title: The American Lung Association (ALA) Lung Health Cohort

Key Details

Gender

All

Age Range

25 Years - 35 Years

Study Type

OBSERVATIONAL

Enrollment

4000

Start Date

2021-10-29

Completion Date

2026-09

Last Updated

2026-02-04

Healthy Volunteers

Yes

Conditions

Lung Diseases

Inclusion Criteria: 1- Age 25-35 years at the time of the baseline examination 2- Able to read and understand English or Spanish 3 -Has a social security number 4- Resident (citizen or non-citizen) of the United States (US) for at least 12 months prior to examination. Note: Individuals who are residents of the US who have temporarily spent time living outside of the US during the last 12 months (e.g., student exchange program, military posting) are eligible for participation. 5- Willing to provide contact information for at least 2 proxies who are likely to know the whereabouts and vital status of the participant Exclusion Criteria: 1. Severe asthma, which is defined as any of the following: 1. Current (i.e. at the time of the visit) GINA Step 4 or higher therapy (medium dose ICS/LABA or high dose ICS or add-on LAMA; Medium dose = \>250 fluticasone, propionate =100 fluticasone furoate, \>200 beclomethasone, \>400 budesonide, \>220 mometasone). We will accept low-dose ICS/LABA or medium dose ICS. OR 2. 3 or more unscheduled healthcare visits (provider/urgent care/ER) for asthma in the past 12 months OR 3. One asthma hospitalization in the past 12 months 2. History of any chronic lung disease other than asthma including but not limited to COPD, cystic fibrosis, pulmonary fibrosis, pulmonary hypertension 3. Current pregnancy 4. History of cancer other than non-melanoma skin cancer 5. Diagnosed cardiovascular diseases (i.e., congenital heart disease, coronary heart disease) 6. Inability to comply with study procedures, including 1. Inability or unwillingness to provide informed consent 2. Inability to perform study measurements 3. Inability to be contacted by phone (via calls and/or text messaging) or email 7. Any condition in the opinion of the physician that puts the participant at risk by participating in the study (e.g., serious respiratory illness requiring antibiotics or steroids or severe fever at the time of the study visit). 8. Institutionalization

Locations (37)

University Of Alabama

Birmingham, Alabama, United States

University of Arizona-Tuscon

Tucson, Arizona, United States

University of California, Los Angeles

Los Angeles, California, United States

University of California, San Francisco

San Francisco, California, United States

University of Colorado

Aurora, Colorado, United States

National Jewish Health

Denver, Colorado, United States

Nemours Children's Jacksonville

Jacksonville, Florida, United States

University of Florida, Jacksonville

Jacksonville, Florida, United States

University of Illinois at Chicago

Chicago, Illinois, United States

Northwestern University

Chicago, Illinois, United States

Rush Universtiy

Chicago, Illinois, United States

University of Chicago

Chicago, Illinois, United States

St. Vincent's Health System

Indianapolis, Indiana, United States

University of Iowa

Iowa City, Iowa, United States

University of Kansas

Kansas City, Kansas, United States

Johns Hopkins University

Baltimore, Maryland, United States

Brigham and Women's

Boston, Massachusetts, United States

University of Michigan

Ann Arbor, Michigan, United States

Presbyterian Brooklyn Methodist Hospital

Brooklyn, New York, United States

New York Medical College

Hawthorne, New York, United States

New York University

New York, New York, United States

Mt. Sinai, NYC

New York, New York, United States

Columbia University

New York, New York, United States

Cornell University

New York, New York, United States

University of Rochester

Rochester, New York, United States

University of North Carolina Hospital

Chapel Hill, North Carolina, United States

Duke University

Durham, North Carolina, United States

Wake Forest School of Medicine

Winston-Salem, North Carolina, United States

Ohio State University

Columbus, Ohio, United States

Temple University

Philadelphia, Pennsylvania, United States

University of Pittsburg-Emphysema/COPD Research Center

Pittsburgh, Pennsylvania, United States

Medical University of South Carolina

Charleston, South Carolina, United States

Vanderbilt University Medical Center

Nashville, Tennessee, United States

Baylor College of Medicine

Houston, Texas, United States

University of Vermont

Colchester, Vermont, United States

University of Washington

Seattle, Washington, United States

University of Wisconsin Madison

Madison, Wisconsin, United States

Clinical Research Directory

American Lung Association (ALA) Lung Health Cohort

Summary

Key Details

Conditions

Eligibility Criteria

Locations (37)