Tundra Space

Tundra Space

Clinical Research Directory

Browse clinical research sites, groups, and studies.

Back to Studies
ACTIVE NOT RECRUITING
NCT04543617
PHASE3

A Study of Atezolizumab With or Without Tiragolumab in Participants With Unresectable Esophageal Squamous Cell Carcinoma Whose Cancers Have Not Progressed Following Definitive Concurrent Chemoradiotherapy

Sponsor: Hoffmann-La Roche

View on ClinicalTrials.gov

Summary

The purpose of this study is to evaluate the efficacy and safety of tiragolumab plus atezolizumab compared with placebo in participants with unresectable esophageal squamous cell carcinoma (or those who are unable or unwilling to undergo surgery) and whose cancers have not progressed following definitive concurrent chemoradiotherapy (dCRT). Participants will be randomized in a 1:1:1 ratio to receive either tiragolumab plus atezolizumab (Arm A), tiragolumab matching placebo plus atezolizumab (Arm B), or double placebo (Arm C).

Official title: A Phase III, Randomized, Double-Blind, Placebo-Controlled Study of Atezolizumab With or Without Tiragolumab (Anti-TIGIT Antibody) in Patients With Unresectable Esophageal Squamous Cell Carcinoma Whose Cancers Have Not Progressed Following Definitive Concurrent Chemoradiotherapy

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

760

Start Date

2020-09-28

Completion Date

2027-03-31

Last Updated

2026-01-20

Healthy Volunteers

No

Interventions

DRUG

Tiragolumab

Tiragolumab at a fixed dose of 600 milligrams (mg) administered by intravenous (IV) infusion every 3 weeks (Q3W) on Day 1 of each 21-day cycle.

DRUG

Atezolizumab

Atezolizumab at a fixed dose of 1200 mg administered by IV infusion Q3W on Day 1 of each 21-day cycle.

DRUG

Tiragolumab Matching Placebo

Tiragolumab matching placebo administered by IV infusion Q3W on Day 1 of each 21-day cycle.

DRUG

Atezolizumab Matching Placebo

Atezolizumab matching placebo administered by IV infusion Q3W on Day 1 of each 21-day cycle.

Locations (165)

Florida Cancer Specialists - Fort Myers (Broadway)

Fort Myers, Florida, United States

Cancer Center of Kansas

Wichita, Kansas, United States

Great Lakes Cancer Center

Williamsville, New York, United States

Instituto de Investigaciones Metabolicas (Idim)

Buenos Aires, Argentina

Fundacion Favaloro

Buenos Aires, Argentina

Centro Oncologico Riojano Integral (CORI)

La Rioja, Argentina

Princess Alexandra Hospital

Woolloongabba, Queensland, Australia

Austin Health

Heidelberg, Victoria, Australia

St John of God Hospital

Subiaco, Western Australia, Australia

Tiroler Landeskrankenanstalten Ges.M.B.H.

Innsbruck, Austria

Klinikum Klagenfurt am Wörthersee

Klagenfurt, Austria

Ordensklinikum Linz Barmherzige Schwestern

Linz, Austria

AKH - Medizinische Universität Wien

Vienna, Austria

UZ Antwerpen

Edegem, Belgium

UZ Leuven Gasthuisberg

Leuven, Belgium

CHU de Liège (Sart Tilman)

Liège, Belgium

Anyang Tumor Hosptial

Anyang, China

Cancer Hospital Chinese Academy of Medical Sciences.

Beijing, China

Affiliated Hospital of Bengbu Medical College

Bengbu, China

Hunan Cancer Hospital

Changsha, China

Heping Hospital Affiliated to Changzhi Medical College

Changzhi, China

Changzhou Cancer hospital

Changzhou, China

Sichuan Provincial Cancer Hospital

Chengdu, China

West China Hospital, Sichuan University

Chengdu, China

Chongqing Cancer Hospital

Chongqing, China

Chongqing Sanxia Central Hospital

Chongqing, China

Fujian Cancer Hospital

Fuzhou, China

Sun Yet-sen University Cancer Center

Guangzhou, China

Nanfang Hospital, Southern Medical University

Guangzhou, China

Zhejiang Cancer Hospital

Hangzhou, China

Jieyang People's Hospital

Jieyang, China

Shandong Cancer Hospital

Jinan, China

Affiliated Hospital of Jining Medical University

Jining, China

The First People's Hospital of Lian Yun Gang

Lianyungang, China

Lishui Central Hospital

Lishui, China

The First Affiliated Hospital to Henan University of Science and Technology

Luoyang, China

Affiliated Drum Tower Hospital of Nanjing University Medical School

Nanjing, China

Shanghai Chest Hospital

Shanghai, China

Fudan University Shanghai Cancer Center

Shanghai, China

Cancer Hospital of Shantou University Medical College

Shantou, China

Liaoning cancer Hospital & Institute

Shenyang, China

Cancer Hospital Chinese Academy of Medical Sciences Shenzhen Center

Shenzhen, China

Hebei Medical University Fourth Hospital

Shijiazhuang, China

Tianjin Cancer Hospital

Tianjin, China

Wuhan Union Hospital Tongji Medical College, Huazhong University of Science and Technology

Wuhan, China

Hubei Cancer Hospital

Wuhan, China

The First Affiliated Hospital of Xiamen University

Xiamen, China

Zhongshan Hospital Xiamen University

Xiamen, China

The First Affiliated Hospital of Xinxiang Medical University

Xinxiang, China

The Affiliated Hospital of Xuzhou Medical College

Xuzhou, China

Subei People's Hospital of Jiangsu province

Yangzhou, China

CHRU De Brest - Hopital Morvan - Institut De Cancerologie Et D'Hematologie

Brest, France

CHU Dijon Bourgogne Hôpital François Mitterand

Dijon, France

Hopital Claude Huriez

Lille, France

Centre Leon Berard

Lyon, France

Hopital Timone Adultes

Marseille, France

Centre Antoine Lacassagne

Nice, France

European Hospital Georges Pompidou (HEGP)

Paris, France

Hopital Du Haut-Leveque

Pessac, France

Chu La Miletrie

Poitiers, France

Hopital Rangueil

Toulouse, France

Universitätsklinikum Essen Klinik f.Strahlentherapie

Essen, Germany

Kliniken Essen-Mitte, Evang. Huyssens-Stiftung, Klinik für Internistische Onkologie / Haematologie

Essen, Germany

Klinik für Gastroenterologie und Gastrointestinale Onkologie der UMG

Göttingen, Germany

Universitaetsklinikum Leipzig

Leipzig, Germany

Med. Fak. d. Otto-von-Guericke-Universität

Magdeburg, Germany

Klinikum der Philipps-Universität Marburg

Marburg, Germany

Universitätsklinikum Klinik u.Poliklinik f.Strahlentherapie

Regensburg, Germany

Evgenidio Hospital "Agia Trias"

Athens, Greece

Univ General Hosp Heraklion

Heraklion, Greece

Euromedical General Clinic of Thessaloniki

Thessaloniki, Greece

Pécsi Tudományegyetem

Pécs, Hungary

Szegedi Tudományegyetem

Szeged, Hungary

Hadassah Ein Karem Hospital

Jerusalem, Israel

Rambam Health Corporation

Rambam, Israel

Tel Aviv Sourasky Medical Ctr

Tel Aviv, Israel

Università degli Studi della Campania Luigi Vanvitelli

Naples, Campania, Italy

Ospedale Degli Infermi - Faenza

Faenza, Emilia-Romagna, Italy

Asu Fc S. M. Della Misericordia

Udine, Friuli Venezia Giulia, Italy

Istituto Oncologico Veneto IRCCS

Padova, Veneto, Italy

Aichi Cancer Center Hospital

Aichi, Japan

National Cancer Center Hospital East

Chiba, Japan

Hiroshima University Hospital

Hiroshima, Japan

Kobe University Hospital

Hyōgo, Japan

Yokohama City University Medical Center

Kanagawa, Japan

Kanagawa Cancer Center

Kanagawa, Japan

Tohoku University Hospital

Miyagi, Japan

Niigata Cancer Center Hospital

Niigata, Japan

Osaka International Cancer Institute

Osaka, Japan

The University of Osaka Hospital

Osaka, Japan

Saitama Medical University International Medical Center

Saitama, Japan

Saitama Cancer Center

Saitama, Japan

Shizuoka Cancer Center

Shizuoka, Japan

The Cancer Institute Hospital of JFCR

Tokyo, Japan

Keio University Hospital

Tokyo, Japan

International Cancer Institute (ICI)

Eldoret, Kenya

The Aga Khan University-Kenya.

Nairobi, Kenya

Centre Hospitalier Universitaire Hassan II

Fes, Morocco

Centre Hospitalier Universitaire Mohamed VI

Marrakesh, Morocco

Institut National D'oncologie Sidi Med Benabdellah

Rabat, Morocco

Tauranga Hospital, Clinical Trials Unit

Tauranga, New Zealand

Centrum Onkologii

Bydgoszcz, Poland

Centrum Onkologii Ziemi Lubelskiej Im. ?W. Jana Z Dukli

Lublin, Poland

Szpital Kliniczny MSWiA z Warmi?sko-Mazurskim Centrum Onkologii

Olsztyn, Poland

Wielkopolskie Centrum Onkologii im. Marii Sk?odowskiej-Curie

Późna, Poland

NIO im Marii Sklodowskiej-Curie

Warsaw, Poland

Dolno?l?skie Centrum Onkologii

Wroc?aw, Poland

HUC

Coimbra, Portugal

Centro Hospitalar do Porto ? Hospital de Santo António

Porto, Portugal

IPO do Porto

Porto, Portugal

Krasnoyarsk Regional Oncology Dispensary n.a. Krizhanovsky

Krasnoyarsk, Krasnodarskiy Kray, Russia

Russian Oncology Research Center n.a. N.N. Blokhin Dpt of Clinical Pharmacology and Chemotherapy

Moscow, Moscow Oblast, Russia

Republican Clinical Oncology Dispensary of Ministry of Healthcare of Tatarstan Republic

Kazan', Tatarstan Republic, Russia

City Oncological Hospital

Izhevsk, Udmurtiya Republic, Russia

Limited Liability Company "RC Medical"

Novosibirsk, Russia

Regional Oncology Dispensary

Tomsk, Russia

Limpopo Cancer Research Institute

Polokwane, South Africa

Cancercare

Port Elizabeth, South Africa

Eugene Marais Hospital

Pretoria, South Africa

Kyungpook National University Chilgok Hospital

Daegu, South Korea

Ajou University Medical Center

Gyeonggi-do, South Korea

Chonnam National University Hwasun Hospital

Jeollanam-do, South Korea

Severance Hospital, Yonsei University Health System

Seoul, South Korea

Asan Medical Center

Seoul, South Korea

Samsung Medical Center

Seoul, South Korea

Korea University Guro Hospital

Seoul, South Korea

Complejo Hospitalario Universitario A Coruña (CHUAC)

A Coruña, LA Coruna, Spain

Hospital Univ. Central de Asturias

Oviedo, Principality of Asturias, Spain

Hospital Universitari Vall d'Hebron

Barcelona, Spain

Hospital Clinic I Provincial

Barcelona, Spain

Hospital Universitario Reina Sofia

Córdoba, Spain

Fundacion Jimenez Diaz

Madrid, Spain

Hospital Regional Universitario Carlos Haya

Málaga, Spain

Hospital Clinico Universitario de Valencia

Valencia, Spain

Hospital La Fe

Valencia, Spain

Inselspital Bern, Insel-Gruppe AG

Bern, Switzerland

UniversitätsSpital Zürich

Zurich, Switzerland

Chang Gung Medical Foundation - Kaohsiung;Oncology

Kaohisung, Taiwan

China Medical University Hospital

Taichung, Taiwan

National Cheng Kung University Hospital

Tainan, Taiwan

Chi-Mei Medical Centre

Tainan, Taiwan

National Taiwan University Hospital

Taipei, Taiwan

Taipei Veterans General Hospital

Taipei, Taiwan

Vajira Hospital

Bangkok, Thailand

Chulalongkorn Hospital

Bangkok, Thailand

Ramathibodi Hospital

Bangkok, Thailand

Siriraj Hospital

Bangkok, Thailand

Songklanagarind Hospital

Songkhla, Thailand

Baskent University Adana Dr. Turgut Noyan Practice and Research Hospital

Adana, Turkey (Türkiye)

Ankara University Faculty of Medicine Cebeci Hospital

Ankara, Turkey (Türkiye)

Ankara City Hospital

Ankara, Turkey (Türkiye)

Ataturk University Medical Faculty Yakutiye Research Hospital Medical Oncology Department

Erzurum, Turkey (Türkiye)

Inonu University Faculty of Medicine Turgut Ozal Medical Center

Malatya, Turkey (Türkiye)

Van Yuzuncu Yil University Hospital

Van, Turkey (Türkiye)

Municipal Noncommercial Institution Regional Center of Oncology

Kharkiv, Kharkiv Governorate, Ukraine

Zhytomyr Regional Oncology Center

Zhytomyr, KIEV Governorate, Ukraine

Vinnytsya Regional Clinical Oncology Dispensary

Vinnytsia, Podolia Governorate, Ukraine

RCI Sumy Regional Clinical Oncological Dispensary

Sumy, Ukraine

Royal Bournemouth Hospital

Bournemouth, United Kingdom

Addenbrookes Hospital

Cambridge, United Kingdom

Ninewells Hospital

London, United Kingdom

Royal Marsden Hospital - Fulham

London, United Kingdom

Clatterbridge Cancer Centre

Metropolitan Borough of Wirral, United Kingdom

Royal Marsden Hospital (Sutton)

Sutton, United Kingdom

New Cross Hospital

Wolverhampton, United Kingdom